Basic information
Locus name	AT1G74360
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Protein degradation/modification:protein kinase and phosphatases
Effect for Senescence	unclear
Gene Description	leucine-rich repeat transmembrane protein kinase, putative similar to brassinosteroid insensitive 1 GB:AAC49810 (putative receptor protein kinase); contains Pfam profiles: PF00560 Leucine Rich Repeat (17 repeats), PF00069 Eukaryotic protein kinase domain
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85
Gene Ontology	biological process protein phosphorylation molecular function ATP binding protein binding protein kinase activity protein serine/threonine kinase activity
Sequence	AT1G74360.1 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT1G74360.1  miRNA: ath-miR395a miRNA: ath-miR395a mfe: -26.1 kcal/mol  p-value: 0.088631  position:  1820  target 5' U   A     G      U  C    A 3'             GAG UUCCU CAAGCA CU UCAG              CUC AAGGG GUUUGU GA AGUC   miRNA  3'           G                5'  target: AT1G74360.1  miRNA: ath-miR395d miRNA: ath-miR395d mfe: -26.1 kcal/mol  p-value: 0.069444  position:  1820  target 5' U   A     G      U  C    A 3'             GAG UUCCU CAAGCA CU UCAG              CUC AAGGG GUUUGU GA AGUC   miRNA  3'           G                5'  target: AT1G74360.1  miRNA: ath-miR395e miRNA: ath-miR395e mfe: -26.1 kcal/mol  p-value: 0.087290  position:  1820  target 5' U   A     G      U  C    A 3'             GAG UUCCU CAAGCA CU UCAG              CUC AAGGG GUUUGU GA AGUC   miRNA  3'           G                5'
Ortholog Group
Ortholog Groups: OG5_156618	Accession Taxon NP_565084 ( AT1G74360 ) Arabidopsis thaliana NP_001050316 Oryza sativa Japonica Group NP_001060176 Oryza sativa Japonica Group NP_001061538 Oryza sativa Japonica Group e_gw1.159.72.1 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_270004 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_141000051 Physcomitrella patens subsp. patens 30138.m004028 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description SUPERFAMILY SSF52058 2.4E-48 74 359 No hit NA PANTHER PTHR24420 0.0 93 1089 No hit NA SMART SM00369 6.7 110 134 IPR003591 Leucine-rich repeat, typical subtype Pfam PF12799 6.4E-7 111 157 IPR025875 Leucine rich repeat 4 ProSiteProfiles PS51450 6.6 112 134 IPR001611 Leucine-rich repeat ProSiteProfiles PS51450 7.5 136 160 IPR001611 Leucine-rich repeat SMART SM00369 94.0 156 182 IPR003591 Leucine-rich repeat, typical subtype Pfam PF00560 0.4 158 177 IPR001611 Leucine-rich repeat Pfam PF12799 1.1E-6 253 291 IPR025875 Leucine rich repeat 4 ProSiteProfiles PS51450 5.2 277 299 IPR001611 Leucine-rich repeat SUPERFAMILY SSF52058 3.9E-57 287 473 No hit NA SMART SM00369 140.0 299 323 IPR003591 Leucine-rich repeat, typical subtype ProSiteProfiles PS51450 5.4 301 324 IPR001611 Leucine-rich repeat Pfam PF13516 1.2 323 339 No hit NA ProSiteProfiles PS51450 5.1 325 347 IPR001611 Leucine-rich repeat Pfam PF13516 0.4 372 394 No hit NA SMART SM00369 32.0 372 396 IPR003591 Leucine-rich repeat, typical subtype ProSiteProfiles PS51450 5.4 374 396 IPR001611 Leucine-rich repeat ProSiteProfiles PS51450 5.0 398 420 IPR001611 Leucine-rich repeat SMART SM00369 24.0 420 443 IPR003591 Leucine-rich repeat, typical subtype Pfam PF13855 5.9E-8 421 481 No hit NA ProSiteProfiles PS51450 6.1 422 444 IPR001611 Leucine-rich repeat SMART SM00369 16.0 444 468 IPR003591 Leucine-rich repeat, typical subtype ProSiteProfiles PS51450 4.9 446 468 IPR001611 Leucine-rich repeat SUPERFAMILY SSF52058 3.9E-57 575 678 No hit NA SMART SM00369 93.0 593 617 IPR003591 Leucine-rich repeat, typical subtype ProSiteProfiles PS51450 4.7 595 617 IPR001611 Leucine-rich repeat ProSiteProfiles PS51450 4.5 618 640 IPR001611 Leucine-rich repeat Pfam PF13516 0.8 640 660 No hit NA ProSiteProfiles PS51450 5.5 642 665 IPR001611 Leucine-rich repeat SUPERFAMILY SSF56112 2.4E-75 797 1086 IPR011009 Protein kinase-like domain ProSiteProfiles PS50011 39.9 814 1095 IPR000719 Protein kinase, catalytic domain SMART SM00220 1.1E-39 814 1087 IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain Pfam PF00069 6.9E-49 816 1083 IPR000719 Protein kinase, catalytic domain ProSitePatterns PS00107 NA 820 843 IPR017441 Protein kinase, ATP binding site ProSitePatterns PS00108 NA 937 949 IPR008271 Serine/threonine-protein kinase, active site
Subcellular Localization
Localization 1 Localization mitochondria Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization plasma membrane Evidence SUBAcon Pubmed ID 23180787