Basic information
Locus name	AT2G02870
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Protein degradation/modification
Effect for Senescence	unclear
Gene Description	kelch repeat-containing F-box family protein weak similarity to Kelch-like protein 5 (Swiss-Prot:Q96PQ7) [Homo sapiens]; contains Pfam profiles PF01344: Kelch motif, PF00646: F-box domain
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85
Gene Ontology	molecular function protein binding
Sequence	AT2G02870.1 | Genomic | mRNA | CDS | Protein AT2G02870.2 | Genomic | mRNA | CDS | Protein AT2G02870.3 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT2G02870.1  miRNA: ath-miR407 miRNA: ath-miR407 mfe: -18.1 kcal/mol  p-value: 0.089527  position:  1411  target 5' U  G U    A            G 3'             GC G GAAG AUAUGAUUUGGA              UG U UUUC UAUACUAAAUUU   miRNA  3'    G      A              5'  target: AT2G02870.2  miRNA: ath-miR407 miRNA: ath-miR407 mfe: -18.1 kcal/mol  p-value: 0.086447  position:  1308  target 5' U  G U    A            G 3'             GC G GAAG AUAUGAUUUGGA              UG U UUUC UAUACUAAAUUU   miRNA  3'    G      A              5'  target: AT2G02870.3  miRNA: ath-miR407 miRNA: ath-miR407 mfe: -18.1 kcal/mol  p-value: 0.086722  position:  1315  target 5' U  G U    A            G 3'             GC G GAAG AUAUGAUUUGGA              UG U UUUC UAUACUAAAUUU   miRNA  3'    G      A              5'
Ortholog Group
Ortholog Groups: OG5_156288	Accession Taxon NP_001030959 Arabidopsis thaliana NP_001030960 ( AT2G02870 ) Arabidopsis thaliana NP_172885 Arabidopsis thaliana NP_178390 Arabidopsis thaliana NP_001049113 Oryza sativa Japonica Group estExt_Genewise1.C_1230022 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_1360090 Physcomitrella patens subsp. patens 28005.m000023 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description SUPERFAMILY SSF117281 4.3E-47 177 464 No hit NA SMART SM00612 0.4 215 259 IPR006652 Kelch repeat type 1 PANTHER PTHR24413 1.2E-31 229 412 No hit NA Pfam PF01344 2.1E-5 248 294 IPR006652 Kelch repeat type 1 SMART SM00612 0.0 261 307 IPR006652 Kelch repeat type 1 Pfam PF01344 5.1E-9 296 342 IPR006652 Kelch repeat type 1 SMART SM00612 0.0 308 356 IPR006652 Kelch repeat type 1
Subcellular Localization
Localization	nucleus
Evidence	SUBAcon
Pubmed ID	23180787