Basic information
Locus name	AT3G22370
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Redox regulation:Antioxidants
Effect for Senescence	unclear
Gene Description	alternative oxidase 1a, mitochondrial (AOX1A) identical to GB:Q39219 [SP|Q39219] from [Arabidopsis thaliana]
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85
Gene Ontology	biological process oxidation-reduction process molecular function alternative oxidase activity
Pathway	KEGG map00121 (EC 1.-.-.-) map00231 (EC 1.-.-.-) map00520 (EC 1.-.-.-) map00592 (EC 1.-.-.-) map00633 (EC 1.-.-.-) map00860 (EC 1.-.-.-) map00906 (EC 1.-.-.-) map00950 (EC 1.-.-.-) map00981 (EC 1.-.-.-)
Sequence	AT3G22370.1 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT3G22370.1  miRNA: ath-miR1886 miRNA: ath-miR1886 mfe: -21.6 kcal/mol  p-value: 0.025087  position:  172  target 5' A     C U C            C 3'             CGGUC G A GGUUUCGUCUCA              GUUAG U U CUAAAGUAGAGU   miRNA  3' G     U                  5'  target: AT3G22370.1  miRNA: ath-miR834 miRNA: ath-miR834 mfe: -27.6 kcal/mol  p-value: 0.012363  position:  986  target 5' C    C G            G 3'             UGCU C GCUAUUGCUAUU              AUGG G CGAUGACGAUGG   miRNA  3' A    U G            U 5'  target: AT3G22370.1  miRNA: ath-miR870 miRNA: ath-miR870 mfe: -24.5 kcal/mol  p-value: 0.022455  position:  519  target 5' A    U            U   C 3'             GAUC GAAGAAGCAUCA GUU              CUAG CUUCUUUGUGGU UAA   miRNA  3'                   U   U 5'
Ortholog Group
Ortholog Groups: OG5_130283	Accession Taxon NP_188875 Arabidopsis thaliana NP_188876 ( AT3G22370 ) Arabidopsis thaliana NP_189399 Arabidopsis thaliana NP_201226 Arabidopsis thaliana NP_564395 Arabidopsis thaliana CMI072C Cyanidioschyzon merolae strain 10D 129968 Chlamydomonas reinhardtii 77667 Chlamydomonas reinhardtii NP_001046676 Oryza sativa Japonica Group NP_001047839 Oryza sativa Japonica Group NP_001053758 Oryza sativa Japonica Group NP_001053759 Oryza sativa Japonica Group estExt_gwp_GeneWisePlus.C_Chr_09.00010226 Ostreococcus tauri fgenesh1_pg.scaffold_183000009 Physcomitrella patens subsp. patens 30063.m001399 Ricinus communis e_gw1.20.88.1 Thalassiosira pseudonana CCMP1335 estExt_gwp_gw1.C_chr_200172 Thalassiosira pseudonana CCMP1335 XP_002955181 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PIRSF PIRSF005229 1.1E-155 1 354 IPR002680 Alternative oxidase PANTHER PTHR31803 3.0E-174 17 354 No hit NA Pfam PF01786 9.8E-87 144 336 IPR002680 Alternative oxidase
Subcellular Localization
Localization 1 Localization mitochondria Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization mitochondrion Evidence SUBAcon Pubmed ID 23180787