Basic information
Locus name	AT4G21980
Alias	APG8a
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Nutrient recycling:Autophagy
Effect for Senescence	delay
Gene Description	autophagy 8a (APG8a) identical to autophagy 8a [Arabidopsis thaliana] GI:19912151
Evidence	Molecular and physioogic evidence:GUS staining [Ref 1]; Genomic evidence:microarray data [Ref 2]
References	1: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85 2: Slavikova S, Shy G, Yao Y, Glozman R, Levanony H, Pietrokovski S, Elazar Z, Galili G The autophagy-associated Atg8 gene family operates both under favourable growth conditions and under starvation stresses in Arabidopsis plants. J. Exp. Bot. 2005 Nov;56(421):2839-49
Sequence	AT4G21980.1 | Genomic | mRNA | CDS | Protein AT4G21980.2 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
Ortholog Group
Ortholog Groups: OG5_126969	Accession Taxon NP_001078424 ( AT4G21980 ) Arabidopsis thaliana NP_001154497 Arabidopsis thaliana NP_176395 Arabidopsis thaliana NP_178631 Arabidopsis thaliana NP_182042 Arabidopsis thaliana NP_191623 Arabidopsis thaliana NP_192371 Arabidopsis thaliana NP_567504 Arabidopsis thaliana NP_567642 Arabidopsis thaliana NP_849298 Arabidopsis thaliana NP_849395 Arabidopsis thaliana NP_850431 Arabidopsis thaliana 59275 Chlamydomonas reinhardtii ACO68142 Micromonas sp. RCC299 NP_001053929 Oryza sativa Japonica Group NP_001059767 Oryza sativa Japonica Group NP_001061171 Oryza sativa Japonica Group estExt_genewise1.C_Chr_01.00010658 Ostreococcus tauri estExt_Genewise1.C_2490044 Physcomitrella patens subsp. patens estExt_Genewise1.C_260093 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_2090070 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_2090080 Physcomitrella patens subsp. patens gw1.209.48.1 Physcomitrella patens subsp. patens 29636.m000773 Ricinus communis 29842.m003584 Ricinus communis 30064.m000481 Ricinus communis 30064.m000482 Ricinus communis 30174.m008829 Ricinus communis e_gw1.2.784.1 Thalassiosira pseudonana CCMP1335 XP_002952089 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10969 1.8E-77 1 117 IPR004241 Autophagy protein Atg8 ubiquitin-like SUPERFAMILY SSF54236 4.7E-43 3 117 No hit NA Pfam PF02991 5.8E-51 15 117 IPR004241 Autophagy protein Atg8 ubiquitin-like
Mutant Image
atg8a (SALK_045344C) mutant exhibited early senescence phenotype compared with wild type Col-0 (7-week-old).
Subcellular Localization
Localization 1 Localization cytosol Evidence SUBAcon Pubmed ID 23180787
Localization 2 Localization cytosol,vacuole Evidence SUBAcon Pubmed ID 23180787