Basic information
Locus name	AT4G14880
Alias	OLD3/OAS-A1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Protein degradation/modification
Effect for Senescence	delay
Gene Description	OAS-A1 encodes a cytosolic O-acetylserine (thiol) lyase.O-acetylserine (thiol) lyase (OAS-TL) catalyses the final step of cysteine biosynthesis
Evidence	Genetic evidence:Mutant [Ref 1, Ref 2]
References	1: Jing HC, Sturre MJ, Hille J, Dijkwel PP Arabidopsis onset of leaf death mutants identify a regulatory pathway controlling leaf senescence. Plant J. 2002 Oct;32(1):51-63 2: Shirzadian-Khorramabad R, Jing HC, Everts GE, Schippers JH, Hille J, Dijkwel PP A mutation in the cytosolic O-acetylserine (thiol) lyase induces a genome-dependent early leaf death phenotype in Arabidopsis. BMC Plant Biol. 2010;10:80
Gene Ontology	biological process cysteine biosynthetic process from serine molecular function cysteine synthase activity
Pathway	KEGG map00270 (EC 2.5.1.47) map00450 (EC 2.5.1.47) map00920 (EC 2.5.1.47)
Sequence	AT4G14880.1 | Genomic | mRNA | CDS | Protein AT4G14880.2 | Genomic | mRNA | CDS | Protein AT4G14880.3 | Genomic | mRNA | CDS | Protein AT4G14880.4 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	old3-1
Mutant/Transgenic	mutant
Ecotype	Ler
Mutagenesis type	EMS
Ortholog Group
Ortholog Groups: OG5_126662	Accession Taxon NP_001031956 Arabidopsis thaliana NP_001031957 Arabidopsis thaliana NP_001078628 Arabidopsis thaliana NP_181903 Arabidopsis thaliana NP_191535 Arabidopsis thaliana NP_193224 Arabidopsis thaliana NP_198154 Arabidopsis thaliana NP_198155 Arabidopsis thaliana NP_566243 Arabidopsis thaliana NP_849386 ( AT4G14880 ) Arabidopsis thaliana NP_851022 Arabidopsis thaliana NP_851023 Arabidopsis thaliana NP_851087 Arabidopsis thaliana NP_974843 Arabidopsis thaliana CMS037C Cyanidioschyzon merolae strain 10D CMT313C Cyanidioschyzon merolae strain 10D 175651 Chlamydomonas reinhardtii 183351 Chlamydomonas reinhardtii 189320 Chlamydomonas reinhardtii 196886 Chlamydomonas reinhardtii 205986 Chlamydomonas reinhardtii ACO61071 Micromonas sp. RCC299 ACO61205 Micromonas sp. RCC299 NP_001045577 Oryza sativa Japonica Group NP_001051262 Oryza sativa Japonica Group NP_001056819 Oryza sativa Japonica Group NP_001056820 Oryza sativa Japonica Group NP_001057882 Oryza sativa Japonica Group NP_001057884 Oryza sativa Japonica Group NP_001057885 Oryza sativa Japonica Group NP_001067319 Oryza sativa Japonica Group 1200010309 Ostreococcus tauri gw1.07.00.279.1 Ostreococcus tauri e_gw1.17.76.1 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_710078 Physcomitrella patens subsp. patens fgenesh2_pg.scaffold_105000044 Physcomitrella patens subsp. patens 29747.m001062 Ricinus communis 29844.m003285 Ricinus communis 30128.m008638 Ricinus communis 30128.m008639 Ricinus communis 30128.m008641 Ricinus communis 30128.m008642 Ricinus communis 30128.m008643 Ricinus communis e_gw1.2.308.1 Thalassiosira pseudonana CCMP1335 XP_002946965 Volvox carteri f. nagariensis XP_002948674 Volvox carteri f. nagariensis XP_002949438 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10314 1.6E-181 2 318 No hit NA SUPERFAMILY SSF53686 6.7E-103 4 313 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily Pfam PF00291 1.9E-57 10 295 IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily TIGRFAM TIGR01136 4.3E-136 10 308 IPR005856 Cysteine synthase K/M TIGRFAM TIGR01139 1.9E-143 10 308 IPR005859 Cysteine synthase A ProSitePatterns PS00901 NA 35 53 IPR001216 Cysteine synthase/cystathionine beta-synthase P-phosphate-binding site
Subcellular Localization
Localization	cytosol
Evidence	SUBAcon
Pubmed ID	23180787