Basic information
Locus name	At3g12130
Alias	KHZ1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	transcription factor:CCCH zinc-finger
Effect for Senescence	promote
Gene Description	CCCH zinc-finger and KH domain protein
Evidence	Genetic evidence:transgene [Ref 1]
References	1: Yan Z, Jia J, Yan X, Shi H, Han Y. Arabidopsis KHZ1 and KHZ2, two novel non-tandem CCCH zinc-finger and K-homolog domain proteins, have redundant roles in the regulation of flowering and senescence. Plant Mol Biol. 2017 Dec;95(6):549-565. doi: 10.1007/s11103-017-0667-8. Epub 2017 Oct 26.
Gene Ontology	molecular function RNA binding nucleic acid binding zinc ion binding
Sequence	AT3G12130.1 | mRNA | CDS | Protein AT3G12130.2 | mRNA | CDS | Protein
Mutant information
Mutated 1 Mutant name khz1 (SALK_057095C) Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA
Mutated 2 Mutant name khz1khz2 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA;cross
Mutated 3 Mutant name KHZ1-OE Mutant/Transgenic transgene Ecotype Col-0 Mutagenesis type transgenic
Ortholog Group
Ortholog Groups: OG5_150344	Accession Taxon NP_196295 Arabidopsis thaliana NP_566412 ( At3g12130 ) Arabidopsis thaliana NP_001046176 Oryza sativa Japonica Group NP_001054179 Oryza sativa Japonica Group NP_001058083 Oryza sativa Japonica Group 1800010021 Ostreococcus tauri e_gw1.66.209.1 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_590273 Physcomitrella patens subsp. patens 27843.m000161 Ricinus communis 27843.m000162 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10288 1.6E-145 15 244 No hit NA ProSiteProfiles PS50103 12.8 36 64 IPR000571 Zinc finger, CCCH-type SMART SM00356 0.2 36 63 IPR000571 Zinc finger, CCCH-type SUPERFAMILY SSF90229 2.6E-6 37 63 No hit NA Pfam PF00642 1.9E-4 38 61 IPR000571 Zinc finger, CCCH-type SUPERFAMILY SSF54791 3.4E-15 102 183 No hit NA SMART SM00322 2.1E-10 112 182 IPR004087 K Homology domain ProSiteProfiles PS50084 14.1 113 177 IPR004088 K Homology domain, type 1 Pfam PF00013 6.6E-12 115 177 IPR004088 K Homology domain, type 1 ProSiteProfiles PS50103 16.8 213 240 IPR000571 Zinc finger, CCCH-type SMART SM00356 1.2E-7 213 239 IPR000571 Zinc finger, CCCH-type SUPERFAMILY SSF90229 2.8E-8 213 243 No hit NA Pfam PF00642 3.7E-9 214 239 IPR000571 Zinc finger, CCCH-type
Mutant Image
The OE plants of KHZ1 and KHZ2 showed early leaf senescence significantly, whereas the khz1 khz2 double mutants showed delayed senescence of leaf and the whole plant.
Subcellular Localization
Localization	nucleus
Evidence	SUBAcon
Pubmed ID	23180787