Basic information
Locus name	AT5G06460
Alias	ATUBA2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	ATUBA2; FUNCTIONS IN: ubiquitin-protein ligase activity, ubiquitin activating enzyme activity; INVOLVED IN: ubiquitin-dependent protein catabolic process, protein ubiquitination; LOCATED IN: nucleus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-activating enzyme repeat (InterPro:IPR000127), Ubiquitin-activating enzyme, E1, active site (InterPro:IPR018074), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), Ubiquitin-activating enzyme, E1 (InterPro:IPR018075), NAD(P)-binding (InterPro:IPR016040), Ubiquitin-activating enzyme, E1-like (InterPro:IPR000011); BEST Arabidopsis thaliana protein match is: ATUBA1; ubiquitin activating enzyme/ ubiquitin-protein ligase (TAIR:AT2G30110.1); Has 12625 Blast hits to 7983 proteins in 1305 species: Archae - 249; Bacteria - 5773; Metazoa - 1663; Fungi - 924; Plants - 420; Viruses - 0; Other Eukaryotes - 3596 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process cellular protein modification process molecular function small protein activating enzyme activity
Pathway
Sequence	AT5G06460.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_127070	Accession Taxon NP_565693 Arabidopsis thaliana NP_568168 ( AT5G06460 ) Arabidopsis thaliana CMI034C Cyanidioschyzon merolae strain 10D 191903 Chlamydomonas reinhardtii ACO64838 Micromonas sp. RCC299 NP_001049821 Oryza sativa Japonica Group NP_001060725 Oryza sativa Japonica Group NP_001065539 Oryza sativa Japonica Group gw1.07.00.17.1 Ostreococcus tauri e_gw1.160.107.1 Physcomitrella patens subsp. patens e_gw1.322.22.1 Physcomitrella patens subsp. patens e_gw1.74.147.1 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_50269 Physcomitrella patens subsp. patens 29820.m000987 Ricinus communis 29932.m000611 Ricinus communis estExt_thaps1_ua_kg.C_chr_30287 Thalassiosira pseudonana CCMP1335 XP_002947244 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10953 0.0 1 1076 No hit NA SUPERFAMILY SSF69572 1.1E-100 69 456 IPR009036 Molybdenum cofactor biosynthesis, MoeB TIGRFAM TIGR01408 0.0 69 1076 IPR018075 Ubiquitin-activating enzyme, E1 Pfam PF00899 7.5E-18 93 206 IPR000594 UBA/THIF-type NAD/FAD binding fold PRINTS PR01849 1.5E-66 96 120 IPR000011 Ubiquitin/SUMO-activating enzyme E1 PRINTS PR01849 1.5E-66 211 238 IPR000011 Ubiquitin/SUMO-activating enzyme E1 ProSitePatterns PS00536 NA 434 442 IPR018074 Ubiquitin-activating enzyme, E1, active site SUPERFAMILY SSF69572 9.8E-128 467 967 IPR009036 Molybdenum cofactor biosynthesis, MoeB Pfam PF00899 3.7E-35 489 631 IPR000594 UBA/THIF-type NAD/FAD binding fold PRINTS PR01849 1.5E-66 519 542 IPR000011 Ubiquitin/SUMO-activating enzyme E1 PRINTS PR01849 1.5E-66 566 591 IPR000011 Ubiquitin/SUMO-activating enzyme E1 Pfam PF10585 4.3E-18 634 677 IPR019572 Ubiquitin-activating enzyme ProSitePatterns PS00865 NA 651 659 IPR018074 Ubiquitin-activating enzyme, E1, active site PRINTS PR01849 1.5E-66 720 747 IPR000011 Ubiquitin/SUMO-activating enzyme E1 Pfam PF02134 2.3E-6 776 828 IPR000127 Ubiquitin-activating enzyme repeat Pfam PF02134 9.7E-22 876 943 IPR000127 Ubiquitin-activating enzyme repeat Pfam PF09358 5.9E-36 950 1072 IPR018965 Ubiquitin-activating enzyme e1, C-terminal SMART SM00985 7.8E-50 950 1072 IPR018965 Ubiquitin-activating enzyme e1, C-terminal
Subcellular Localization
Localization	nucleus
Evidence	SUBAcon
Pubmed ID	23180787