Basic information
Locus name	AT4G24400
Alias	CIPK8
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Protein degradation/modification
Effect for Senescence	unclear
Gene Description	CBL-INTERACTING PROTEIN KINASE 8 (CIPK8); FUNCTIONS IN: protein kinase activity, kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine protein kinase (InterPro:IPR002290), NAF/FISL domain (InterPro:IPR018451), Tyrosine protein kinase (InterPro:IPR001245), Serine/threonine protein kinase-related (InterPro:IPR017442), Protein kinase-like (InterPro:IPR011009), Serine/threonine protein kinase, active site (InterPro:IPR008271), NAF (InterPro:IPR004041), Protein kinase, core (InterPro:IPR000719); BEST Arabidopsis thaliana protein match is: SOS2 (SALT OVERLY SENSITIVE 2); kinase/ protein kinase (TAIR:AT5G35410.1); Has 96898 Blast hits to 95249 proteins in 3304 species: Archae - 81; Bacteria - 8660; Metazoa - 42144; Fungi - 8806; Plants - 18293; Viruses - 487; Other Eukaryotes - 18427 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process protein phosphorylation signal transduction molecular function ATP binding protein kinase activity protein serine/threonine kinase activity
Sequence	AT4G24400.1 | Genomic | mRNA | CDS | Protein AT4G24400.2 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_153204	Accession Taxon NP_001078442 Arabidopsis thaliana NP_194171 ( AT4G24400 ) Arabidopsis thaliana NP_198391 Arabidopsis thaliana NP_001043259 Oryza sativa Japonica Group NP_001058024 Oryza sativa Japonica Group e_gw1.205.33.1 Physcomitrella patens subsp. patens estExt_Genewise1.C_2110074 Physcomitrella patens subsp. patens 28320.m001148 Ricinus communis 29596.m000693 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR24343 2.6E-163 6 270 No hit NA SUPERFAMILY SSF56112 4.5E-92 6 280 IPR011009 Protein kinase-like domain Pfam PF00069 3.0E-73 9 262 IPR000719 Protein kinase, catalytic domain ProSiteProfiles PS50011 52.6 9 262 IPR000719 Protein kinase, catalytic domain SMART SM00220 1.0E-106 9 262 IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain ProSitePatterns PS00107 NA 15 47 IPR017441 Protein kinase, ATP binding site ProSitePatterns PS00108 NA 128 140 IPR008271 Serine/threonine-protein kinase, active site ProSiteProfiles PS50816 11.8 302 326 IPR018451 NAF/FISL domain Pfam PF03822 5.9E-20 304 363 IPR004041 NAF domain
Subcellular Localization
Localization	cytosol
Evidence	SUBAcon
Pubmed ID	23180787