Basic information
Locus name	AT5G25900
Alias	GA3
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway
Effect for Senescence	unclear
Gene Description	GA REQUIRING 3 (GA3); FUNCTIONS IN: ent-kaurene oxidase activity, oxygen binding; INVOLVED IN: gibberellin biosynthetic process, gibberellic acid mediated signaling; LOCATED IN: chloroplast outer membrane, endoplasmic reticulum, microsome; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: CYP71B35; electron carrier/ heme binding / iron ion binding / monooxygenase/ oxygen binding (TAIR:AT3G26310.1); Has 22608 Blast hits to 22252 proteins in 1231 species: Archae - 32; Bacteria - 2311; Metazoa - 10309; Fungi - 3741; Plants - 5270; Viruses - 3; Other Eukaryotes - 942 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process oxidation-reduction process molecular function heme binding iron ion binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
Pathway	Reactome REACT_13433
Sequence	AT5G25900.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_134366	Accession Taxon NP_197962 ( AT5G25900 ) Arabidopsis thaliana NP_568024 Arabidopsis thaliana NP_001057429 Oryza sativa Japonica Group NP_001057903 Oryza sativa Japonica Group NP_001057905 Oryza sativa Japonica Group NP_001057907 Oryza sativa Japonica Group NP_001057909 Oryza sativa Japonica Group NP_001057912 Oryza sativa Japonica Group e_gw1.334.32.1 Physcomitrella patens subsp. patens 30170.m013942 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR24279 0.0 14 509 No hit NA SUPERFAMILY SSF48264 1.4E-96 42 507 IPR001128 Cytochrome P450 Pfam PF00067 9.4E-78 47 488 IPR001128 Cytochrome P450 PRINTS PR00463 1.1E-30 72 91 IPR002401 Cytochrome P450, E-class, group I PRINTS PR00463 1.1E-30 96 117 IPR002401 Cytochrome P450, E-class, group I PRINTS PR00463 1.1E-30 325 351 IPR002401 Cytochrome P450, E-class, group I PRINTS PR00463 1.1E-30 367 385 IPR002401 Cytochrome P450, E-class, group I PRINTS PR00463 1.1E-30 408 432 IPR002401 Cytochrome P450, E-class, group I PRINTS PR00463 1.1E-30 444 454 IPR002401 Cytochrome P450, E-class, group I ProSitePatterns PS00086 NA 447 456 IPR017972 Cytochrome P450, conserved site PRINTS PR00463 1.1E-30 454 477 IPR002401 Cytochrome P450, E-class, group I
Subcellular Localization
Localization	endoplasmic reticulum
Evidence	SUBAcon
Pubmed ID	23180787