Basic information
Locus name	AT4G22220
Alias	ISU1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Others
Effect for Senescence	unclear
Gene Description	ISU1; FUNCTIONS IN: structural molecule activity; INVOLVED IN: iron-sulfur cluster assembly; LOCATED IN: mitochondrion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NIF system FeS cluster assembly, NifU, N-terminal (InterPro:IPR002871), ISC system FeS cluster assembly, IscU scaffold (InterPro:IPR011339); BEST Arabidopsis thaliana protein match is: ISU3 (ISCU-LIKE 3); structural molecule (TAIR:AT4G04080.1); Has 3579 Blast hits to 3579 proteins in 1083 species: Archae - 68; Bacteria - 1960; Metazoa - 117; Fungi - 106; Plants - 54; Viruses - 0; Other Eukaryotes - 1274 (source: NCBI BLink).
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process iron-sulfur cluster assembly molecular function iron ion binding iron-sulfur cluster binding
Sequence	AT4G22220.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_127020	Accession Taxon NP_186751 Arabidopsis thaliana NP_192317 Arabidopsis thaliana NP_193953 ( AT4G22220 ) Arabidopsis thaliana CMR318C Cyanidioschyzon merolae strain 10D 187899 Chlamydomonas reinhardtii ACO64114 Micromonas sp. RCC299 ACO68532 Micromonas sp. RCC299 NP_001043783 Oryza sativa Japonica Group NP_001056355 Oryza sativa Japonica Group e_gw1.01.00.615.1 Ostreococcus tauri e_gw1.507.10.1 Physcomitrella patens subsp. patens gw1.39.289.1 Physcomitrella patens subsp. patens gw1.76.138.1 Physcomitrella patens subsp. patens 30147.m013940 Ricinus communis e_gw1.9.199.1 Thalassiosira pseudonana CCMP1335
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10093 3.3E-88 6 163 No hit NA Pfam PF01592 1.3E-55 28 154 IPR002871 NIF system FeS cluster assembly, NifU, N-terminal SUPERFAMILY SSF82649 9.9E-47 28 154 No hit NA TIGRFAM TIGR01999 1.1E-66 29 152 IPR011339 ISC system FeS cluster assembly, IscU scaffold
Subcellular Localization
Localization 1 Localization mitochondria Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization mitochondrion Evidence SUBAcon Pubmed ID 23180787