Basic information
Locus name	AT1G02340
Alias	HFR1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category
Effect for Senescence	promote
Gene Description	ranscription factor HFR1 (long hypocotyl in FR light1), which is the non-DNA binding atypical HLH factor
Evidence	Genetic evidence [Ref 1]
References	1: Bulgakov VP, Koren OG. Basic Protein Modules Combining Abscisic Acid and Light Signaling in Arabidopsis Front Plant Sci. 2022 Jan 3;12:808960. doi: 10.3389/fpls.2021.808960. eCollection 2021.
Gene Ontology	molecular function protein dimerization activity
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT1G02340.1  miRNA: ath-miR826 miRNA: ath-miR826 mfe: -26.5 kcal/mol  p-value: 0.013376  position:  277  target 5' A             G      C 3'             ACG GUCUAAAAU GGGCUA              UGC UAGGUUUUG CCUGAU   miRNA  3' G   A         G        5'  target: AT1G02340.1  miRNA: ath-miR831 miRNA: ath-miR831 mfe: -25.3 kcal/mol  p-value: 0.015269  position:  590  target 5' G              A    G G 3'             AAGAAGAG ACGAG AGAU A              UUCUUCUC UGCUU UCUA U   miRNA  3' G        A     C    G   5'  target: AT1G02340.1  miRNA: ath-miR837-5p miRNA: ath-miR837-5p mfe: -22.8 kcal/mol  p-value: 0.047353  position:  243  target 5' A                    G 3'             GAAA GAGCAAGAAG UGAU              CUUU CUUGUUCUUU ACUA   miRNA  3' A    G          G      5'
Cross Link
Database Entry ID E-value Start End InterPro ID Description ProSiteProfiles PS50888 13.8 134 183 IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain SMART SM00353 5.3E-9 139 189 IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain PANTHER PTHR12565 1.5E-28 144 286 No hit NA Pfam PF00010 2.0E-7 144 184 IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain SUPERFAMILY SSF47459 8.1E-14 144 194 IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Subcellular Localization
Localization 1 Localization nucleus Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization nucleus Evidence SUBAcon Pubmed ID 23180787