Basic information
Locus name	AT1G51660
Alias	ATMKK4
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Signal transduction (MKK)
Effect for Senescence	unclear
Gene Description	ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 (ATMKK4); FUNCTIONS IN: MAP kinase kinase activity, kinase activity; INVOLVED IN: stomatal complex patterning, MAPKKK cascade, floral organ abscission, defense response, incompatible interaction, stomatal complex development
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process protein phosphorylation molecular function ATP binding protein kinase activity protein serine/threonine kinase activity
Sequence	AT1G51660.1 | Genomic | mRNA | CDS | Protein
miRNA Interaction
Details	target: AT1G51660.1  miRNA: ath-miR854a miRNA: ath-miR854a mfe: -36.9 kcal/mol  p-value: 0.001177  position: 1311  target 5' C      G C             U  3'             CUCCUC U CUCUGUCCUCGUC                 GAGGAG A GGGAUAGGAGUAG      miRNA  3'        G                  5'  target: AT1G51660.1  miRNA: ath-miR854b miRNA: ath-miR854b mfe: -36.9 kcal/mol  p-value: 0.000648  position: 1311  target 5' C      G C             U  3'             CUCCUC U CUCUGUCCUCGUC                 GAGGAG A GGGAUAGGAGUAG      miRNA  3'        G                  5'  target: AT1G51660.1  miRNA: ath-miR854c miRNA: ath-miR854c mfe: -36.9 kcal/mol  p-value: 0.000541  position: 1311  target 5' C      G C             U  3'             CUCCUC U CUCUGUCCUCGUC                 GAGGAG A GGGAUAGGAGUAG      miRNA  3'        G                  5'  target: AT1G51660.1  miRNA: ath-miR854d miRNA: ath-miR854d mfe: -36.9 kcal/mol  p-value: 0.001035  position: 1311  target 5' C      G C             U  3'             CUCCUC U CUCUGUCCUCGUC                 GAGGAG A GGGAUAGGAGUAG      miRNA  3'        G                  5'  target: AT1G51660.1  miRNA: ath-miR854e miRNA: ath-miR854e mfe: -36.9 kcal/mol  p-value: 0.000355  position: 1311  target 5' C      G C             U  3'             CUCCUC U CUCUGUCCUCGUC                 GAGGAG A GGGAUAGGAGUAG      miRNA  3'        G                  5'
Ortholog Group
Ortholog Groups: OG5_150257	Accession Taxon NP_173271 Arabidopsis thaliana NP_175577 ( AT1G51660 ) Arabidopsis thaliana NP_177492 Arabidopsis thaliana NP_187274 Arabidopsis thaliana NP_188759 Arabidopsis thaliana NP_001048341 Oryza sativa Japonica Group NP_001057028 Oryza sativa Japonica Group estExt_Genewise1.C_160199 Physcomitrella patens subsp. patens estExt_fgenesh1_pm.C_1140016 Physcomitrella patens subsp. patens 29748.m000383 Ricinus communis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR24361 4.2E-143 11 360 No hit NA SUPERFAMILY SSF56112 5.9E-79 77 362 IPR011009 Protein kinase-like domain ProSiteProfiles PS50011 46.4 79 334 IPR000719 Protein kinase, catalytic domain SMART SM00220 4.2E-86 79 334 IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain Pfam PF00069 7.6E-66 82 334 IPR000719 Protein kinase, catalytic domain ProSitePatterns PS00107 NA 85 108 IPR017441 Protein kinase, ATP binding site ProSitePatterns PS00108 NA 192 204 IPR008271 Serine/threonine-protein kinase, active site
Subcellular Localization
Localization 1 Localization nucleus Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization cytoplasm and nucleus Evidence Localization with GFP-ORF fusion protein (GFP:cDNA) Pubmed ID 15610358
Localization 3 Localization cytosol Evidence SUBAcon Pubmed ID 23180787