Basic information
Locus name	AT5G10480
Alias	PAS2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Signal transduction:tyrosine phosphatase
Effect for Senescence	unclear
Gene Description	Protein tyrosine phosphatase-like involved in cell division and differentiation. Interacts with CDKA;1 only in its phosphorylated form, preventing dephosphorylation. Overexpression slowed down cell division in suspension cell cultures at the G2-to-M transition and early mitosis and inhibited Arabidopsis seedling growth.
Evidence	Genetic evidence:Mutant and transgene [Ref 1, Ref 2, Ref 3, Ref 4, Ref 5]
References	1: Bach L, Michaelson LV, Haslam R, Bellec Y, Gissot L, Marion J, Da Costa M, Boutin JP, Miquel M, Tellier F, Domergue F, Markham JE, Beaudoin F, Napier JA, Faure JD The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development. Proc. Natl. Acad. Sci. U.S.A. 2008 Sep 23;105(38):14727-31 2: Da Costa M, Bach L, Landrieu I, Bellec Y, Catrice O, Brown S, De Veylder L, Lippens G, Inze D, Faure JD Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A. Plant Cell 2006 Jun;18(6):1426-37 3: Bellec Y, Harrar Y, Butaeye C, Darnet S, Bellini C, Faure JD Pasticcino2 is a protein tyrosine phosphatase-like involved in cell proliferation and differentiation in Arabidopsis. Plant J. 2002 Dec;32(5):713-22 4: Yanovsky MJ, Luppi JP, Kirchbauer D, Ogorodnikova OB, Sineshchekov VA, Adam E, Kircher S, Staneloni RJ, Sch_fer E, Nagy F, Casal JJ Missense mutation in the PAS2 domain of phytochrome A impairs subnuclear localization and a subset of responses. Plant Cell 2002 Jul;14(7):1591-603 5: Faure JD, Vittorioso P, Santoni V, Fraisier V, Prinsen E, Barlier I, Van Onckelen H, Caboche M, Bellini C The PASTICCINO genes of Arabidopsis thaliana are involved in the control of cell division and differentiation. Development 1998 Mar;125(5):909-18
Pathway	KEGG map00040 (EC 4.2.1.-) map00061 (EC 4.2.1.-) map00121 (EC 4.2.1.-) map00253 (EC 4.2.1.-) map00350 (EC 4.2.1.-) map00362 (EC 4.2.1.-) map00363 (EC 4.2.1.-) map00400 (EC 4.2.1.-) map00520 (EC 4.2.1.-) map00623 (EC 4.2.1.-) map00626 (EC 4.2.1.-) map00650 (EC 4.2.1.-) map00860 (EC 4.2.1.-) map00903 (EC 4.2.1.-)
Sequence	AT5G10480.1 | Genomic | mRNA | CDS | Protein AT5G10480.2 | Genomic | mRNA | CDS | Protein
Mutant information
Mutated 1 Mutant name 35S-PAS2:GFP overexpression line Mutant/Transgenic transgenic Ecotype Col-0 Mutagenesis type transgene
Mutated 2 Mutant name pas2-1 Mutant/Transgenic mutant Ecotype Col-0 Mutagenesis type T-DNA insertion_knock out
Ortholog Group
Ortholog Groups: OG5_127323	Accession Taxon NP_001078566 Arabidopsis thaliana NP_196610 ( AT5G10480 ) Arabidopsis thaliana NP_200785 Arabidopsis thaliana CMR006C Cyanidioschyzon merolae strain 10D 188251 Chlamydomonas reinhardtii 95439 Chlamydomonas reinhardtii ACO63818 Micromonas sp. RCC299 ACO64497 Micromonas sp. RCC299 NP_001042032 Oryza sativa Japonica Group NP_001052344 Oryza sativa Japonica Group NP_001055759 Oryza sativa Japonica Group fgenesh1_pm.C_Chr_13.0001000047 Ostreococcus tauri estExt_Genewise1.C_1550082 Physcomitrella patens subsp. patens estExt_Genewise1.C_300032 Physcomitrella patens subsp. patens 29788.m000339 Ricinus communis 29913.m000154 Ricinus communis fgenesh1_pg.C_chr_7000164 Thalassiosira pseudonana CCMP1335 XP_002951479 Volvox carteri f. nagariensis XP_002955943 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR11035 1.2E-92 2 195 IPR007482 Protein-tyrosine phosphatase-like, PTPLA Pfam PF04387 1.7E-60 30 193 IPR007482 Protein-tyrosine phosphatase-like, PTPLA
Subcellular Localization
Localization 1 Localization cytosol,nucleus Evidence SUBAcon Pubmed ID 23180787
Localization 2 Localization endoplasmic reticulum Evidence SUBAcon Pubmed ID 23180787