Basic information
Locus name	AT1G09940
Alias	HEMA2
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Redox regulation
Effect for Senescence	unclear
Gene Description	HEMA2; FUNCTIONS IN: glutamyl-tRNA reductase activity; INVOLVED IN: response to oxidative stress, heme biosynthetic process, tetrapyrrole biosynthetic process, porphyrin biosynthetic process. Gene expression is increased during leaf senescence.
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Breeze E, Harrison E, McHattie S, Hughes L, Hickman R, Hill C, Kiddle S, Kim YS, Penfold CA, Jenkins D, Zhang C, Morris K, Jenner C, Jackson S, Thomas B, Tabrett A, Legaie R, Moore JD, Wild DL, Ott S, Rand D, Beynon J, Denby K, Mead A, Buchanan-Wollaston High-resolution temporal profiling of transcripts during Arabidopsis leaf senescence reveals a distinct chronology of processes and regulation. Plant Cell 2011 Mar;23(3):873-94
Gene Ontology	biological process oxidation-reduction process tetrapyrrole biosynthetic process molecular function NADP binding glutamyl-tRNA reductase activity
Pathway	KEGG map00860 (EC 1.2.1.70) MetaCyc PWY-5188
Sequence	AT1G09940.1 | Genomic | mRNA | CDS | Protein
Ortholog Group
Ortholog Groups: OG5_130465	Accession Taxon NP_172465 ( AT1G09940 ) Arabidopsis thaliana NP_176125 Arabidopsis thaliana NP_180683 Arabidopsis thaliana CMJ054C Cyanidioschyzon merolae strain 10D 183460 Chlamydomonas reinhardtii ACO70597 Micromonas sp. RCC299 NP_001064991 Oryza sativa Japonica Group 1100010072 Ostreococcus tauri e_gw1.13.83.1 Physcomitrella patens subsp. patens e_gw1.256.9.1 Physcomitrella patens subsp. patens estExt_fgenesh1_pg.C_3810029 Physcomitrella patens subsp. patens 29804.m001510 Ricinus communis 30170.m013615 Ricinus communis estExt_Genewise1.C_chr_40732 Thalassiosira pseudonana CCMP1335 XP_002951823 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR32118 0.0 30 528 No hit NA PIRSF PIRSF000445 6.2E-152 86 528 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase Hamap MF_00087 25.9 87 512 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase SUPERFAMILY SSF69742 8.2E-40 87 243 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal TIGRFAM TIGR01035 1.0E-107 88 493 IPR000343 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase Pfam PF05201 8.3E-44 91 242 IPR015895 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, N-terminal ProSitePatterns PS00747 NA 184 207 IPR018214 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, conserved site SUPERFAMILY SSF51735 6.5E-27 246 404 No hit NA Pfam PF01488 6.7E-41 261 396 IPR006151 Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase SUPERFAMILY SSF69075 2.0E-18 408 496 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain Pfam PF00745 5.6E-26 410 515 IPR015896 Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain
Subcellular Localization
Localization	plastid
Evidence	SUBAcon
Pubmed ID	23180787