Basic information
Locus name	AT5G64930
Alias	CPR5/OLD1/HYS1
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Hormone response pathway:SA
Effect for Senescence	promote
Gene Description	A genetic locus involved in leaf senescence in response to ethylene. Lines carrying recessive alleles exhibit early leaf senescence both in air and upon ethylene exposure. The etiolated old1 seedlings exhibited a hypersensitive triple response. Regulator of expression of pathogenesis-related (PR) genes. Participates in signal transduction pathways involved in plant defense (systemic acquired resistance -SAR).
Evidence	Genetic evidence:Mutant [Ref 1, Ref 2, Ref 3, Ref 4, Ref 5]
References	1: Jing HC, Sturre MJ, Hille J, Dijkwel PP Arabidopsis onset of leaf death mutants identify a regulatory pathway controlling leaf senescence. Plant J. 2002 Oct;32(1):51-63 2: Jing HC, Schippers JH, Hille J, Dijkwel PP Ethylene-induced leaf senescence depends on age-related changes and OLD genes in Arabidopsis. J. Exp. Bot. 2005 Nov;56(421):2915-23 3: Jing HC, Hebeler R, Oeljeklaus S, Sitek B, Stuhler K, Meyer HE, Sturre MJ, Hille J, Warscheid B, Dijkwel PP Early leaf senescence is associated with an altered cellular redox balance in Arabidopsis cpr5/old1 mutants. Plant Biol (Stuttg) 2008 Sep;10 Suppl 1:85-98 4: Boubourakas IN, Fukuta S, Kyriakopoulou PE Sensitive and rapid detection of peach latent mosaic viroid by the reverse transcription loop-mediated isothermal amplification. J. Virol. Methods 2009 Sep;160(1-2):63-8 5: Jing HC, Dijkwel PP CPR5: A Jack of all trades in plants. Plant Signal Behav 2008 Aug;3(8):562-3
Sequence	AT5G64930.1 | Genomic | mRNA | CDS | Protein
Mutant information
Mutant name	old1-1/cpr5
Mutant/Transgenic	mutant
Ecotype	Ler
Mutagenesis type	EMS
miRNA Interaction
Details	target: AT5G64930.1  miRNA: ath-miR414 miRNA: ath-miR414 mfe: -35.6 kcal/mol  p-value: 0.000045  position:  124  target 5' A                 A  A 3'             GACGAUGAUGAUGAAGA GA              CUGCUACUACUACUUCU CU   miRNA  3' A                 A    5'  target: AT5G64930.1  miRNA: ath-miR830 miRNA: ath-miR830 mfe: -24.4 kcal/mol  p-value: 0.006474  position:  668  target 5' C                     A 3'             ACC GAGCUAUUUG AGAGGG              UGG UUUGAUAAAC UCUUCU   miRNA  3' U   A          C        5'
Ortholog Group
Ortholog Groups: OG5_156660	Accession Taxon NP_569003 ( AT5G64930 ) Arabidopsis thaliana ACO63692 Micromonas sp. RCC299 NP_001045208 Oryza sativa Japonica Group NP_001048248 Oryza sativa Japonica Group fgenesh1_pg.C_Chr_02.0001000252 Ostreococcus tauri estExt_fgenesh1_pg.C_2860013 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_12000198 Physcomitrella patens subsp. patens 29719.m000318 Ricinus communis
Mutant Image
cpr5 mutant exhibited early senescence.
Subcellular Localization
Localization	cytosol,nucleus
Evidence	SUBAcon
Pubmed ID	23180787