Basic information
Locus name	AT1G17745
Organism	Arabidopsis thaliana
Taxonomic identifier	[NCBI]
Function category	Lipid/Carbohydrate metabolism
Effect for Senescence	unclear
Gene Description	D-3-phosphoglycerate dehydrogenase / 3-PGDH identical to SP|O04130
Evidence	Genomic evidence:microarray data [Ref 1]
References	1: Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4):567-85
Gene Ontology	biological process metabolic process oxidation-reduction process molecular function NAD binding amino acid binding cofactor binding oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Pathway	KEGG map00260 (EC 1.1.1.95) map00680 (EC 1.1.1.95)
Sequence	AT1G17745.1 | Genomic | mRNA | CDS | Protein
Microarray
Sampling	Buchanan-Wollaston V, Page T, Harrison E, Breeze E, Lim PO, Nam HG, Lin JF, Wu SH, Swidzinski J, Ishizaki K, Leaver CJ. Comparative transcriptome analysis reveals significant differences in gene expression and signalling pathways between developmental and dark/starvation-induced senescence in Arabidopsis. Plant J. 2005 May;42(4)
Comparation	Legends: Col: wild type, indicates the ratio of expression in senescing leaves/green leaves. NahG, coi1 and ein2: indicates the ratio of expression in senescing leaves of mutant/senescing wild type. D/L: ratio of DARK 5d/control. CD: Cell Death, ratio of starved cell suspension culture/control. Genes showing at least 3 fold (ratio) up regulation during leaf senescence.
miRNA Interaction
Details	target: AT1G17745.1  miRNA: ath-miR396a miRNA: ath-miR396a mfe: -26.3 kcal/mol  p-value: 0.016047  position:  874  target 5' G  U                 C 3'             GG UUCGGGAAAGUUG GGA              UC AAGUUCUUUCGAC CCU   miRNA  3' G                A   U 5'  target: AT1G17745.1  miRNA: ath-miR396b miRNA: ath-miR396b mfe: -25.9 kcal/mol  p-value: 0.021275  position:  873  target 5' U   U                 C 3'             GGG UUCGGGAAAGUUG GGA              UUC AAGUUCUUUCGAC CCU   miRNA  3'                   A   U 5'
Ortholog Group
Ortholog Groups: OG5_127006	Accession Taxon NP_195146 Arabidopsis thaliana NP_564034 ( AT1G17745 ) Arabidopsis thaliana NP_566637 Arabidopsis thaliana CMC149C Cyanidioschyzon merolae strain 10D CMT252C Cyanidioschyzon merolae strain 10D 136279 Chlamydomonas reinhardtii 162449 Chlamydomonas reinhardtii 78757 Chlamydomonas reinhardtii ACO66052 Micromonas sp. RCC299 ACO68863 Micromonas sp. RCC299 NP_001054094 Oryza sativa Japonica Group NP_001058248 Oryza sativa Japonica Group NP_001061929 Oryza sativa Japonica Group estExt_gwp_GeneWisePlus.C_Chr_05.00010450 Ostreococcus tauri e_gw1.38.64.1 Physcomitrella patens subsp. patens e_gw1.87.22.1 Physcomitrella patens subsp. patens estExt_gwp_gw1.C_20376 Physcomitrella patens subsp. patens fgenesh1_pg.scaffold_11000203 Physcomitrella patens subsp. patens 29801.m003106 Ricinus communis 30158.m000507 Ricinus communis 30170.m013699 Ricinus communis 35212.m000028 Ricinus communis estExt_fgenesh1_pg.C_chr_16a0073 Thalassiosira pseudonana CCMP1335 estExt_thaps1_ua_kg.C_chr_50295 Thalassiosira pseudonana CCMP1335 fgenesh1_pg.C_chr_2000973 Thalassiosira pseudonana CCMP1335 XP_002950373 Volvox carteri f. nagariensis XP_002956698 Volvox carteri f. nagariensis
Cross Link
Database Entry ID E-value Start End InterPro ID Description PANTHER PTHR10996 2.8E-237 81 491 No hit NA SUPERFAMILY SSF52283 8.3E-36 82 215 No hit NA TIGRFAM TIGR01327 1.6E-165 84 622 IPR006236 D-3-phosphoglycerate dehydrogenase Pfam PF00389 6.4E-37 85 394 IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain SUPERFAMILY SSF51735 1.6E-57 181 363 No hit NA Pfam PF02826 3.7E-61 187 362 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding ProSitePatterns PS00065 NA 224 251 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding ProSitePatterns PS00670 NA 272 294 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding ProSitePatterns PS00671 NA 301 317 IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding SUPERFAMILY SSF143548 1.7E-22 400 546 No hit NA SUPERFAMILY SSF55021 1.4E-11 542 618 No hit NA Pfam PF01842 1.7E-7 556 610 IPR002912 ACT domain
Subcellular Localization
Localization 1 Localization chloroplast Evidence Localization with GFP-fusion protein (GFP:cDNA) Pubmed ID 10737809
Localization 2 Localization plastid Evidence SUBAcon Pubmed ID 23180787