Accession SAMC1386203
Accession in Other Database GSA-Human: HRS047143
Sample name AA_04_RNA
Title AA_04_RNA
Sample type Human sample
Organism Homo sapiens
Description old adult
Attributes *This sample record contains additional controlled-access information that is avaiable from GSA-Human by requesting study HRA000203 in the GSA-Human system.
Release date 2020-08-14
BioProject Accession PRJCA002865
Submitter Wenru  Su  (suwr3@mail.sysu.edu.cn)
Organization Zhongshan Ophthalmic Center,Sun Yat-sen University
Submission date 2023-06-18

Sample Data

Resource name Description
GSA-Human (1) -
HRA000203  (Controlled Access) Age-associated changes in immune cells have been linked with increased risk for infection and cancer. However, a global and detailed characterization of the changes human immune cells undergo with age is lacking. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old research subjects and patients with COVID-19. We found an aging reprogramed immune cell landscape. Notably, aging increased senescent hallmark genes and coronavirus susceptibility gene expression in cell-subtype specificity. Most impressively, COVID-19 increased aging-induced immune cells polarization, inflammation genes and senescent hallmark genes upregulation. An aging-associated dysregulated immune system and upregulated SARS-CoV-2 susceptibility gene expression may account for susceptibility and increased vulnerability of COVID-19 in the elderly.
Related samples
Samples (1)