| Accession |
PRJCA002865 |
| Title |
A human immune cell landscape in aging and COVID-19 |
| Relevance |
Aging |
| Data types |
Whole genome sequencing
Transcriptome or Gene expression
|
| Organisms |
Homo sapiens
|
| Description |
Age-associated changes in immune cells have been linked with increased risk for infection and cancer. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old research subjects and patients with COVID-19. We found an aging reprogramed immune cell landscape. Notably, aging increased senescent hallmark genes and coronavirus susceptibility gene expression in cell-subtype specificity. Most impressively, COVID-19 increased aging-induced immune cells polarization, inflammation genes and senescent hallmark genes upregulation. An aging-associated dysregulated immune system and upregulated SARS-CoV-2 susceptibility gene expression may account for susceptibility and increased vulnerability of COVID-19 in the elderly. |
| Sample scope |
Single cell |
| Release date |
2020-06-16 |
| Publication |
|
| Grants |
| Agency |
program |
Grant ID |
Grant title |
| State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
|
|
2017YFA0105800
|
|
|
|
| Submitter |
Wenru
Su (suwr3@mail.sysu.edu.cn)
|
| Organization |
Zhongshan Ophthalmic Center,Sun Yat-sen University |
| Submission date |
2020-06-16 |
