Accession |
PRJCA002865 |
Title |
A human immune cell landscape in aging and COVID-19 |
Relevance |
Aging |
Data types |
Whole genome sequencing
Transcriptome or Gene expression
|
Organisms |
Homo sapiens
|
Description |
Age-associated changes in immune cells have been linked with increased risk for infection and cancer. Here, we combined scRNA-seq, mass cytometry and scATAC-seq to compare immune cell types in peripheral blood collected from young and old research subjects and patients with COVID-19. We found an aging reprogramed immune cell landscape. Notably, aging increased senescent hallmark genes and coronavirus susceptibility gene expression in cell-subtype specificity. Most impressively, COVID-19 increased aging-induced immune cells polarization, inflammation genes and senescent hallmark genes upregulation. An aging-associated dysregulated immune system and upregulated SARS-CoV-2 susceptibility gene expression may account for susceptibility and increased vulnerability of COVID-19 in the elderly. |
Sample scope |
Single cell |
Release date |
2020-06-16 |
Publication |
|
Grants |
Agency |
program |
Grant ID |
Grant title |
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University
|
|
2017YFA0105800
|
|
|
Submitter |
Wenru
Su (suwr3@mail.sysu.edu.cn)
|
Organization |
Zhongshan Ophthalmic Center,Sun Yat-sen University |
Submission date |
2020-06-16 |