The detail information of Haemophilia A
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: X-linked recessive

Considered a defect: yes

Year key mutation first reported: 2002

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB48 German Boxer 58.4-63.5 cm (male), 54.6-59.7 cm (female) 29.5-36.3 kg (male), females are about 6.8 kg less than male Germany
CB110 German Shepherd Dog 61-66 cm (male), 55.9-61 cm (female) 29.5-40.8 kg (male), 22.7-31.8 kg (female) Germany
CB131 Irish Setter 68.6 cm (male), 63.5 cm (female) 31.8 kg (male), 27.2 kg (female) Ireland
CB161 Miniature Schnauzer 30.5-35.6 cm 5-9.1 kg Germany
Associated Gene
Symbol Description Species Position Other Links
F8 coagulation factor VIII, procoagulant component Canis lupus familiaris ChrX : 126170925 - 126024520 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Kehl,A.,Haaland,A.H.,Langbein-Detsch,I.,Mueller,E.: :
A SINE Insertion in <i>F8</i> Gene Leads to Severe Form of Hemophilia A in a Family of Rhodesian Ridgebacks. Genes (Basel) 12:, 2021.
Pubmed reference: 33494213 . DOI: 10.3390/genes12020134 .
2020 Switonski,M.: :
Impact of gene therapy for canine monogenic diseases on the progress of preclinical studies. J Appl Genet :, 2020.
Pubmed reference: 32189222 . DOI: 10.1007/s13353-020-00554-8 .
2018 Decambron,A.,Manassero,M.,Thibaud,J.L.,Reyes-Gomez,E.,Viateau,V.: :
Bone haemophilic pseudotumour of the ulna: A rare complication of haemophilia in a dog. Vet Comp Orthop Traumatol 30:, 2018.
Pubmed reference: 28763522 . DOI: 10.3415/VCOT-17-01-0002 .
2018 Sun,J.,Shao,W.,Chen,X.,Merricks,E.P.,Wimsey,L.,Abajas,Y.L.,Niemeyer,G.P.,Lothrop,C.D.,Monahan,P.E.,Samulski,R.J.,Nichols,T.C.,Li,C.: :
An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs. Mol Ther Methods Clin Dev 10:257-267, 2018.
Pubmed reference: 30140713 . DOI: 10.1016/j.omtm.2018.07.011 .
2016 Callan,M.B.,Haskins,M.E.,Wang,P.,Zhou,S.,High,K.A.,Arruda,V.R.: :
Successful Phenotype Improvement following Gene Therapy for Severe Hemophilia A in Privately Owned Dogs. PLoS One 11:e0151800, 2016.
Pubmed reference: 27011017 . DOI: 10.1371/journal.pone.0151800 .
2016 Lozier,J.N.,Kloos,M.T.,Merricks,E.P.,Lemoine,N.,Whitford,M.H.,Raymer,R.A.,Bellinger,D.A.,Nichols,T.C.: :
Severe Hemophilia A in a Male Old English Sheep Dog with a C→T Transition that Created a Premature Stop Codon in Factor VIII. Comp Med 66:405-411, 2016.
Pubmed reference: 27780008 .
2016 Nichols,T.C.,Hough,C.,Agersø,H.,Ezban,M.,Lillicrap,D.: :
Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies. J Thromb Haemost 14:894-905, 2016.
Pubmed reference: 26924758 . DOI: 10.1111/jth.13301 .
2016 Wang,Q.,Dong,B.,Firrman,J.,Wu,W.,Roberts,S.,Moore,A.R.,Liu,L.S.,Chin,M.P.,Diao,Y.,Kost,J.,Xiao,W.: :
Evaluation of the biological differences of canine and human factor VIII in gene delivery: Implications in human hemophilia treatment. Gene Ther :, 2016.
Pubmed reference: 27064790 . DOI: 10.1038/gt.2016.34 .
2016 Yen,C.T.,Fan,M.N.,Yang,Y.L.,Chou,S.C.,Yu,I.S.,Lin,S.W.: :
Current animal models of hemophilia: the state of the art. Thromb J 14:22, 2016.
Pubmed reference: 27766048 . DOI: 10.1186/s12959-016-0106-0 .
2015 Dolgin,E.: :
Oral solutions. Sci Am 312:S12-3, 2015.
Pubmed reference: 25597119 .
2015 Sohn,E.: :
Dogged pursuit. Sci Am 312:S18-9, 2015.
Pubmed reference: 25597122 .
2014 Aslanian,M.E.,Sharp,C.R.,Rozanski,E.A.,deLaforcade,A.M.,Rishniw,M.,Brooks,M.B.: :
Clinical outcome after diagnosis of hemophilia A in dogs. J Am Vet Med Assoc 245:677-83, 2014.
Pubmed reference: 25181272 . DOI: 10.2460/javma.245.6.677 .
2014 Christopherson,P.W.,Bacek,L.M.,King,K.B.,Boudreaux,M.K.: :
Two novel missense mutations associated with hemophilia A in a family of Boxers, and a German Shepherd dog. Vet Clin Pathol 43:312-6, 2014.
Pubmed reference: 25040606 . DOI: 10.1111/vcp.12172 .
2014 Gavazza,A.,Lubas,G.,Trotta,M.,Caldin,M.: :
Hemophilia A in a Belgian Shepherd Malinois dog: case report. Res Vet Sci 97:96-8, 2014.
Pubmed reference: 24952680 . DOI: 10.1016/j.rvsc.2014.05.007 .
2014 Ozelo,M.C.,Vidal,B.,Brown,C.,Notley,C.,Hegadorn,C.,Webster,S.,Harpell,L.,Ahlin,J.,Winterborn,A.,Handforth,J.,Arruda,V.R.,Hough,C.,Lillicrap,D.: :
Omental implantation of endothelial progenitor cells in hemophilia dogs results in long-term circulating FVIII antigen and a complex immune response. Blood :, 2014.
Pubmed reference: 24829206 . DOI: 10.1182/blood-2013-12-545780 .
2013 Du,L.M.,Nurden,P.,Nurden,A.T.,Nichols,T.C.,Bellinger,D.A.,Jensen,E.S.,Haberichter,S.L.,Merricks,E.,Raymer,R.A.,Fang,J.,Koukouritaki,S.B.,Jacobi,P.M.,Hawkins,T.B.,Cornetta,K.,Shi,Q.,Wilcox,D.A.: :
Platelet-targeted gene therapy with human factor VIII establishes haemostasis in dogs with haemophilia A. Nat Commun 4:2773, 2013.
Pubmed reference: 24253479 . DOI: 10.1038/ncomms3773 .
2013 Lozier,J.N.,Nichols,T.C.: :
Animal Models of Hemophilia and Related Bleeding Disorders. Semin Hematol 50:175-184, 2013.
Pubmed reference: 23956467 . DOI: 10.1053/j.seminhematol.2013.03.023 .
2012 Agersø,H.,Stennicke,H.R.,Pelzer,H.,Olsen,E.N.,Merricks,E.P.,Defriess,N.A.,Nichols,T.C.,Ezban,M.: :
Pharmacokinetics and pharmacodynamics of turoctocog alfa and N8-GP in haemophilia A dogs. Haemophilia 18:941-7, 2012.
Pubmed reference: 22812621 . DOI: 10.1111/j.1365-2516.2012.02896.x .
2012 Barr,J.W.,McMichael,M.: :
Inherited disorders of hemostasis in dogs and cats. Top Companion Anim Med 27:53-8, 2012.
Pubmed reference: 23031456 . DOI: 10.1053/j.tcam.2012.07.006 .
2012 Dumont,J.A.,Liu,T.,Low,S.C.,Zhang,X.,Kamphaus,G.,Sakorafas,P.,Fraley,C.,Drager,D.,Reidy,T.,McCue,J.,Franck,H.W.,Merricks,E.P.,Nichols,T.C.,Bitonti,A.J.,Pierce,G.F.,Jiang,H.: :
Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs. Blood 119:3024-30, 2012.
Pubmed reference: 22246033 . DOI: 10.1182/blood-2011-08-367813 .
2012 Mischke,R.: :
[Haemophilia A and B in dogs]. Tierarztl Prax Ausg K Kleintiere Heimtiere 40:44-53; quiz 54, 2012.
Pubmed reference: 22331328 .
2012 Sabatino,D.E.,Nichols,T.C.,Merricks,E.,Bellinger,D.A.,Herzog,R.W.,Monahan,P.E.: :
Animal models of hemophilia. Prog Mol Biol Transl Sci 105:151-209, 2012.
Pubmed reference: 22137432 . DOI: 10.1016/B978-0-12-394596-9.00006-8 .
2011 Karpf,D.M.,Kjalke,M.,Thim,L.,Agersø,H.,Merricks,E.P.,Defriess,N.,Nichols,T.C.,Ezban,M.: :
Pharmacokinetics and ex vivo whole blood clot formation of a new recombinant FVIII (N8) in haemophilia A dogs. Haemophilia 17:e963-8, 2011.
Pubmed reference: 21682818 . DOI: 10.1111/j.1365-2516.2011.02580.x .
2011 Knudsen,T.,Kristensen,A.T.,Nichols,T.C.,Agersø,H.,Jensen,A.L.,Kjalke,M.,Ezban,M.,Tranholm,M.: :
Pharmacokinetics, pharmacodynamics and safety of recombinant canine FVIIa in a study dosing one haemophilia A and one haemostatically normal dog. Haemophilia 17:962-70, 2011.
Pubmed reference: 21645178 . DOI: 10.1111/j.1365-2516.2011.02536.x .
2011 Mischke,R.,Wilhelm,C.h.,Czwalinna,A.,Varvenne,M.,Narten,K.,vonDepka,M.: :
Canine haemophilia A caused by a mutation leading to a stop codon. Vet Rec 169:496b, 2011.
Pubmed reference: 21949058 . DOI: 10.1136/vr.d4677 .
2011 Petersen,L.C.,Karpf,D.M.,Agersø,H.,Hermit,M.B.,Pelzer,H.,Persson,E.,Nichols,T.C.,Ezban,M.: :
Intravascular inhibition of factor VIIa and the analogue NN1731 by antithrombin. Br J Haematol 152:99-107, 2011.
Pubmed reference: 21083658 . DOI: 10.1111/j.1365-2141.2010.08432.x .
2010 Finn,J.D.,Ozelo,M.C.,Sabatino,D.E.,Franck,H.W.,Merricks,E.P.,Crudele,J.M.,Zhou,S.,Kazazian,H.H.,Lillicrap,D.,Nichols,T.C.,Arruda,V.R.: :
Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy. Blood 116:5842-8, 2010.
Pubmed reference: 20876851 . DOI: 10.1182/blood-2010-06-288001 .
2010 Nichols,T.C.,Raymer,R.A.,Franck,H.W.,Merricks,E.P.,Bellinger,D.A.,DeFriess,N.,Margaritis,P.,Arruda,V.R.,Kay,M.A.,High,K.A.: :
Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B. Haemophilia :19-23, 2010.
Pubmed reference: 20586797 . DOI: 10.1111/j.1365-2516.2010.02255.x .
2010 Othman,M.,Powell,S.,Hopman,W.M.,Lillicrap,D.: :
Variability of thromboelastographic responses following the administration of rFVIIa to haemophilia A dogs supports the individualization of therapy with a global test of haemostasis. Haemophilia 16:919-25, 2010.
Pubmed reference: 20609015 . DOI: 10.1111/j.1365-2516.2010.02336.x .
2009 Dunning,MD.,Averis,GF.,Pattinson,H.,Targett,M.,Cade,S.,Herrtage,ME.: :
Haemophilia A (factor VIII deficiency) in a litter of Weimaraners. J Small Anim Pract :, 2009.
Pubmed reference: 19508492 . DOI: 10.1111/j.1748-5827.2009.00727.x .
2009 Margaritis,P.,Roy,E.,Aljamali,M.N.,Downey,H.D.,Giger,U.,Zhou,S.,Merricks,E.,Dillow,A.,Ezban,M.,Nichols,T.C.,High,K.A.: :
Successful treatment of canine hemophilia by continuous expression of canine FVIIa. Blood 113:3682-9, 2009.
Pubmed reference: 19109232 . DOI: 10.1182/blood-2008-07-168377 .
2009 Milbauer,L.C.,Enenstein,J.A.,Roney,M.,Solovey,A.,Bodempudi,V.,Nichols,T.C.,Hebbel,R.P.: :
Blood outgrowth endothelial cell migration and trapping in vivo: a window into gene therapy. Transl Res 153:179-89, 2009.
Pubmed reference: 19304277 . DOI: 10.1016/j.trsl.2008.12.009 .
2009 Nichols,TC.,Dillow,AM.,Franck,HW.,Merricks,EP.,Raymer,RA.,Bellinger,DA.,Arruda,VR.,High,KA.: :
Protein replacement therapy and gene transfer in canine models of hemophilia A, hemophilia B, von willebrand disease, and factor VII deficiency. ILAR J 50:144-67, 2009.
Pubmed reference: 19293459 .
2009 Sabatino,D.E.,Freguia,C.F.,Toso,R.,Santos,A.,Merricks,E.P.,Kazazian,H.H.,Nichols,T.C.,Camire,R.M.,Arruda,V.R.: :
Recombinant canine B-domain-deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model. Blood 114:4562-5, 2009.
Pubmed reference: 19770361 . DOI: 10.1182/blood-2009-05-220327 .
2008 Brooks,M.B.,MacNguyen,R.,Hall,R.,Gupta,R.,Booth,J.G.: :
Indirect carrier detection of canine haemophilia A using factor VIII microsatellite markers. Anim Genet 39:278-83, 2008.
Pubmed reference: 18454805 . DOI: 10.1111/j.1365-2052.2008.01726.x .
2008 Prasad,S.,Lillicrap,D.,Labelle,A.,Knappe,S.,Keller,T.,Burnett,E.,Powell,S.,Johnson,K.W.: :
Efficacy and safety of a new-class hemostatic drug candidate, AV513, in dogs with hemophilia A. Blood 111:672-9, 2008.
Pubmed reference: 17978172 . DOI: 10.1182/blood-2007-07-098913 .
2006 Arruda,V.R.: :
Toward gene therapy for hemophilia A with novel adenoviral vectors: successes and limitations in canine models. J Thromb Haemost 4:1215-7, 2006.
Pubmed reference: 16706962 . DOI: 10.1111/j.1538-7836.2006.01964.x .
2006 Jiang,H.,Lillicrap,D.,Patarroyo-White,S.,Liu,T.,Qian,X.,Scallan,C.D.,Powell,S.,Keller,T.,McMurray,M.,Labelle,A.,Nagy,D.,Vargas,J.A.,Zhou,S.,Couto,L.B.,Pierce,G.F.: :
Multiyear therapeutic benefit of AAV serotypes 2, 6, and 8 delivering factor VIII to hemophilia A mice and dogs. Blood 108:107-15, 2006.
Pubmed reference: 16522813 . DOI: 10.1182/blood-2005-12-5115 .
2006 McCormack,W.M.,Seiler,M.P.,Bertin,T.K.,Ubhayakar,K.,Palmer,D.J.,Ng,P.,Nichols,T.C.,Lee,B.: :
Helper-dependent adenoviral gene therapy mediates long-term correction of the clotting defect in the canine hemophilia A model. J Thromb Haemost 4:1218-25, 2006.
Pubmed reference: 16706963 . DOI: 10.1111/j.1538-7836.2006.01901.x .
2006 Sarkar,R.,Mucci,M.,Addya,S.,Tetreault,R.,Bellinger,D.A.,Nichols,T.C.,Kazazian,H.H.: :
Long-term efficacy of adeno-associated virus serotypes 8 and 9 in hemophilia a dogs and mice. Hum Gene Ther 17:427-39, 2006.
Pubmed reference: 16610930 . DOI: 10.1089/hum.2006.17.427 .
2005 Brooks,MB.,Barnas,JL.,Fremont,J.,Ray,J.: :
Cosegregation of a factor VIII microsatellite marker with mild hemophilia A in Golden Retriever dogs. J Vet Intern Med 19:205-10, 2005.
Pubmed reference: 15822565 .
2005 Ko,S.,Tanaka,I.,Kanokogi,H.,Kanehiro,H.,Okayama,J.,Ori,J.,Shima,M.,Yoshioka,A.,Giles,A.,Nakajima,Y.: :
Efficacy of auxiliary partial orthotopic liver transplantation for cure of hemophilia in a canine hemophilia A model. Transplant Proc 37:1131-3, 2005.
Pubmed reference: 15848646 . DOI: 10.1016/j.transproceed.2005.01.003 .
2005 Xu,L.,Nichols,T.C.,Sarkar,R.,McCorquodale,S.,Bellinger,D.A.,Ponder,K.P.: :
Absence of a desmopressin response after therapeutic expression of factor VIII in hemophilia A dogs with liver-directed neonatal gene therapy. Proc Natl Acad Sci U S A 102:6080-5, 2005.
Pubmed reference: 15837921 . DOI: 10.1073/pnas.0409249102 .
2004 Brown,B.D.,Shi,C.X.,Powell,S.,Hurlbut,D.,Graham,F.L.,Lillicrap,D.: :
Helper-dependent adenoviral vectors mediate therapeutic factor VIII expression for several months with minimal accompanying toxicity in a canine model of severe hemophilia A. Blood 103:804-10, 2004.
Pubmed reference: 14512318 . DOI: 10.1182/blood-2003-05-1426 .
2003 Scallan,C.D.,Lillicrap,D.,Jiang,H.,Qian,X.,Patarroyo-White,S.L.,Parker,A.E.,Liu,T.,Vargas,J.,Nagy,D.,Powell,S.K.,Wright,J.F.,Turner,P.V.,Tinlin,S.J.,Webster,S.E.,McClelland,A.,Couto,L.B.: :
Sustained phenotypic correction of canine hemophilia A using an adeno-associated viral vector Blood 102:2031-7, 2003.
Pubmed reference: 12738670 . DOI: 10.1182/blood-2003-01-0292 .
2002 Hough,C.,Kamisue,S.,Cameron,C.,Notley,C.,Tinlin,S.,Giles,A.,Lillicrap,D.: :
Aberrant splicing and premature termination of transcription of the FVIII gene as a cause of severe canine hemophilia A: Similarities with the intron 22 inversion mutation in human hemophilia Thrombosis & Haemostasis 87:659-665, 2002.
Pubmed reference: 12008949 .
2002 Lozier,J.N.,Dutra,A.,Pak,E.,Zhou,N.,Zheng,Z.L.,Nichols,T.C.,Bellinger,D.A.,Read,M.,Morgan,R.A.: :
The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion Proceedings of the National Academy of Sciences of the United States of America 99:12991-12996, 2002.
Pubmed reference: 12242334 . DOI: 10.1073/pnas.192219599 .
2002 Notley,C.,Killoran,A.,Cameron,C.,Wynd,K.,Hough,C.,Lillicrap,D.: :
The canine factor VIII 3 '-untranslated region and a concatemeric hepatocyte nuclear factor 1 regulatory element enhance factor VIII transgene expression in vivo Human Gene Therapy 13:1583-1593, 2002.
Pubmed reference: 12228013 . DOI: 10.1089/10430340260201671 .
2001 Gallo-Penn,A.M.,Shirley,P.S.,Andrews,J.L.,Tinlin,S.,Webster,S.,Cameron,C.,Hough,C.,Notley,C.,Lillicrap,D.,Kaleko,M.,Connelly,S.: :
Systemic delivery of an adenoviral vector encoding canine factor VIII results in short-term phenotypic correction, inhibitor development, and biphasic liver toxicity in hemophilia A dogs Blood 97:107-113, 2001.
Pubmed reference: 11133749 .
2000 Clark,P.,Hooper,C.,MacDonald,M.: :
Haemophilia A in a litter of Siberian huskies New Zealand Veterinary Journal 48:60-62, 2000.
2000 Mischke,R.: :
Influence of factor VIII : C and factor IX activity in plasmas of haemophilic dogs on the activated partial thromboplastin time measured with two commercial reagents Haemophilia 6:135-139, 2000.
Pubmed reference: 10792470 .
2000 Mischke,R.: :
Sensitivity of the reaction time of the resonance thrombogram for factor VIII : C and factor IX deficiencies in the blood of dogs with haemophilia A or B Haemophilia 6:575-580, 2000.
Pubmed reference: 11012705 .
1999 Brooks,M.: :
Hereditary bleeding disorders in dogs and cats Veterinary Medicine 94:555-564, 1999.
1999 Gallo-Penn,A.M.,Shirley,P.S.,Andrews,J.L.,Kayda,D.B.,Pinkstaff,A.M.,Kaloss,M.,Tinlin,S.,Cameron,C.,Notley,C.,Hough,C.,Lillicrap,D.,Kaleko,M.,Connelly,S.: :
In vivo evaluation of an adenoviral vector encoding canine factor VIII: High-level, sustained expression in hemophiliac mice Human Gene Therapy 10:1791-1802, 1999.
Pubmed reference: 10446919 . DOI: 10.1089/10430349950017473 .
1999 Gerber,B.,Taboada,J.,Lothrop,C.D.,Busato,A.,Hosgood,G.,Goodman,S.A.,Gaschen,F.P.: :
Determination of normal values using an automated coagulation timer for activated coagulation time and its application in dogs with hemophilia Journal of Veterinary Internal Medicine 13:433-436, 1999.
Pubmed reference: 10499726 .
1999 Lutze,G.,Kutschmann,K.,Thomae,K.,Franke,D.: :
Successful treatment of canine haemophilia A with porcine factor VIII [German] Praktische Tierarzt 80:664-+, 1999.
1999 Thompson,M.S.,Kreeger,J.M.: :
Acute paraplegia in a puppy with hemophilia A Journal of the American Animal Hospital Association 35:36-37, 1999.
Pubmed reference: 9934926 .
1998 Cameron,C.,Notley,C.,Hoyle,S.,Mcglynn,L.,Hough,C.,Kamisue,S.,Giles,A.,Lillicrap,D.: :
The canine factor VIII cDNA and 5' flanking sequence Thrombosis & Haemostasis 79:317-322, 1998.
Pubmed reference: 9493583 .
1998 Stokol,T.,Parry,B.W.: :
Efficacy of fresh-frozen plasma and cryoprecipitate in dogs with Von-Willebrands-disease or hemophilia a Journal of Veterinary Internal Medicine 12:84-92, 1998.
Pubmed reference: 9560764 .
1997 Clark,P.,Bowden,D.K.,Parry,B.W.: :
Studies to detect carriers of haemophilia A in German Shepherd dogs using diagnostic DNA polymorphisms in the human factor VIII gene Veterinary Journal 153:71-74, 1997.
Pubmed reference: 9125358 .
1997 Clark,P.,Parry,B.W.: :
Cytogenetic analysis of german shepherd dogs with haemophilia a Australian Veterinary Journal 75:521-522, 1997.
Pubmed reference: 9258429 .
1997 Stokol,T.,Trepanier,L.,Parry,B.W.,Finnin,B.C.: :
Pharmacokinetics of von Willebrand factor and factor VIII in canine von-Willebrand-disease and haemophilia A Research in Veterinary Science 63:23-27, 1997.
Pubmed reference: 9368952 .
1997 Wardrop,K.J.,Lewis,D.,Marks,S.,Buss,M.: :
Posttransfusion purpura in a dog with hemophilia a Journal of Veterinary Internal Medicine 11:261-263, 1997.
Pubmed reference: 9298482 .
1996 Connelly,S.,Mount,J.,Mauser,A.,Gardner,J.M.,Kaleko,M.,Mcclelland,A.,Lothrop,C.D.: :
Complete short-term correction of canine hemophilia A by in vivo gene therapy Blood 88:3846-3853, 1996.
Pubmed reference: 8916949 .
1996 Graham,J.B.: :
The haemophilic dogs of Chapel Hill, North Carolina Haemophilia 2:255-258, 1996.
1996 Joseph,S.A.,Brooks,M.B.,Coccari,P.J.,Riback,S.C.: :
Hemophilia A in a German shorthaired pointer - clinical presentations and diagnosis Journal of the American Animal Hospital Association 32:25-28, 1996.
Pubmed reference: 8963732 .
1996 Mischke,R.,Ramirez,P.A.R.,Deniz,A.,Hanies,R.,Otto,K.: :
Haemophilia A in the dog - symptoms, blood coagulation analysis and therapy [German] Berliner und Munchener Tierarztliche Wochenschrift 109:279-287, 1996.
Pubmed reference: 9005837 .
1996 Tennant,B.: :
The problem of inherited diseases .3. Haemophilia in the German Shepherd Journal of Small Animal Practice 37:405-406, 1996.
Pubmed reference: 8872944 .
1995 Stokol,T.,Parry,B.W.: :
Stability of canine factor VIII and von Willebrand factor antigen concentration in the frozen state Research in Veterinary Science 59:156-159, 1995.
Pubmed reference: 8525106 .
1995 Stokol,T.,Parry,B.W.: :
Stability of von Willebrand factor and factor VIII in canine cryoprecipitate under various conditions of storage Research in Veterinary Science 59:152-155, 1995.
Pubmed reference: 8525105 .
1994 Stigler,J.: :
The Factor-VIII-Complex and Its Role in Inherited Coagulation Disorders in Dogs Praktische Tierarzt 75:87, 1994.
1993 Brooks,M.,Catalfamo,J.: :
Buccal Mucosa Bleeding Time Is Prolonged in Canine Models of Primary Hemostatic Disorders Thrombosis and Haemostasis 70:777-780, 1993.
Pubmed reference: 8128434 .
1993 Mansell,P.D.,Parry,B.W.,Anderson,G.A.: :
Detection of Canine Carriers of Haemophilia A Using Factor- VIII Activity and Vonwillebrand Factor Antigen Concentration Preventive Veterinary Medicine 16:133-139, 1993.
1993 Mischke,R.: :
Influence of the Factor-VIII - C-Activity on the Activated Partial Thromboplastin Time (aPTT) in Dogs - Usefulness of the aPTT as a Screening Test for Canine Haemophilia-A Deutsche Tierarztliche Wochenschrift 100:219-222, 1993.
Pubmed reference: 8339706 .
1993 Nichols,T.C.,Bellinger,D.A.,Reddick,R.L.,Smith,S.V.,Koch,G.G.,Davis,K.,Sigman,J.,Brinkhous,K.M.,Griggs,T.R.,Read,M.S.: :
The Roles of von Willebrand Factor and Factor-VIII in Arterial Thrombosis - Studies in Canine von Willebrand Disease and Hemophilia-A Blood 81:2644-2651, 1993.
Pubmed reference: 8490173 .
1993 Stefanon,G.,Stefanon,B.,Dodds,W.J.: :
Inherited and Acquired Canine Bleeding Disorders in Northeastern Italy Canine Practice 18:15-23, 1993.
1993 Tinlin,S.,Webster,S.,Giles,A.R.: :
The Development of Homologous (Canine/Anticanine) Antibodies in Dogs with Haemophilia-A (Factor-VIII Deficiency) - A 10- Year Longitudinal Study Thrombosis and Haemostasis 69:21-24, 1993.
Pubmed reference: 8446933 .
1992 Fitch,R.,Wardrop,J.: :
Hemophilia A in a German Shepherd Dog Canine Practice 17:19-23, 1992.
1992 Mansell,P.D.,Parry,B.W.: :
Effect of Acepromazine, Xylazine and Thiopentone on Factor VIII Activity and Vonwillebrand Factor Antigen Concentration in Dogs Australian Veterinary Journal 69:187-190, 1992.
Pubmed reference: 1530553 .
1992 Mansell,P.D.,Parry,B.W.: :
Changes in Factor 8 Activity and Vonwillebrand-Factor Antigen Concentration with Age in Dogs British Veterinary Journal 148:329-337, 1992.
Pubmed reference: 1498645 . DOI: 10.1016/0007-1935(92)90085-F .
1992 Ni,H.Y.,Giles,A.R.: :
Normalization of the Haemostatic Plugs of Dogs with Haemophilia-A (Factor-VIII Deficiency) Following the Infusion of a Combination of Factor-Xa and Phosphatidylcholine/Phosphatidylserine Vesicles Thrombosis and Haemostasis 67:264-271, 1992.
Pubmed reference: 1621248 .
1991 Grondalen,J.,Sjaastad,O.,Teige,J.: :
Enostosis (Panosteitis) in 3 Dogs Suffering from Hemophilia-A Canine Practice 16:10-14, 1991.
1991 Horvath,L.,Elodi,Z.: :
Hereditary Haemophilia (Haemophilia-A) in a German Shepherd Dog Magyar Allatorvosok Lapja 46:29-32, 1991.
1991 Johnstone,I.B.,Keen,J.,Halbert,A.,Crane,S.: :
Stability of Factor-VIII and Vonwillebrand Factor in Canine Blood Samples During Storage Canadian Veterinary Journal-Revue Veterinaire Canadienne 32:173-175, 1991.
1991 Mansell,P.D.,Parry,B.W.: :
Changes in Factor-8- Coagulant Activity and Vonwillebrand Factor Antigen Concentration After Subcutaneous Injection of Desmopressin in Dogs with Mild Hemophilia-A Journal of Veterinary Internal Medicine 5:191-194, 1991.
Pubmed reference: 1920255 .
1991 Mansell,P.D.,Parry,B.W.: :
Stability of Canine Factor-VIII Activity and Vonwillebrand Factor Antigen Concentration Invitro Research in Veterinary Science 51:313-316, 1991.
Pubmed reference: 1780587 .
1990 Mansell,P.D.,Parry,B.W.,Vanorsouw,P.J.: :
Haemophilia-A in a Family of Miniature Poodles Australian Veterinary Journal 67:420-421, 1990.
Pubmed reference: 2085303 .
1990 Mertens,K.,Briët,E.,Giles,A.R.: :
The role of factor VII in haemostasis: infusion studies of factor VIIa in a canine model of factor VIII deficiency. Thromb Haemost 64:138-44, 1990.
Pubmed reference: 2274919 .
1989 Brinkhous,K.M.,Hedner,U.,Garris,J.B.,Diness,V.,Read,M.S.: :
Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease. Proc Natl Acad Sci U S A 86:1382-6, 1989.
Pubmed reference: 2784006 .
1989 Chabbat,J.,Hampikian-Lenin,S.,Toully,V.,Gaillandre,A.,Péjaudier,L.,Steinbuch,M.: :
A human factor VIIa concentrate and its effects in the hemophilic A dog. Thromb Res 54:603-12, 1989.
Pubmed reference: 2789440 .
1989 Mansell,P.D.,Parry,B.W.: :
Stability of canine factor VIII: coagulant in vitro Canadian Journal of Veterinary Research 53:264-267, 1989.
Pubmed reference: 2504474 .
1988 Fogh,J.M.: :
A study of hemophilia A in German Shepherd dogs in Denmark Veterinary Clinics of North America, Small Animal Practice 18:245-254, 1988.
1988 Fogh,J.M.,Fogh,I.T.: :
Inherited coagulation disorders. Vet Clin North Am Small Anim Pract 18:231-43, 1988.
Pubmed reference: 3282382 .
1988 Giles,A.R.,Tinlin,S.,Hoogendoorn,H.,Fournel,M.A.,Ng,P.,Pancham,N.: :
In vivo characterization of recombinant factor VIII in a canine model of hemophilia A (factor VIII deficiency). Blood 72:335-9, 1988.
Pubmed reference: 3134068 .
1988 Littlewood,J.D.: :
Haemophilia A (factor VIII deficiency) in German Shepherd dogs Journal of Small Animal Practice 29:117-128, 1988.
1988 Parry,B.W.,Holloway,S.A.,Birch,D.J.,Mackin,A.J.: :
Haemophilia A in a cocker spaniel dog. Aust Vet J 65:326-7, 1988.
Pubmed reference: 3196251 .
1988 Parry,B.W.,Howard,M.A.,Mansell,P.D.,Hollaway,S.A.: :
Haemophilia A in German shepherd dogs Australian Veterinary Journal 65:276-279, 1988.
Pubmed reference: 3142453 .
1988 VanderVelden,P.,Giles,A.R.: :
A detailed morphological evaluation of the evolution of the haemostatic plug in normal, factor VII and factor VIII deficient dogs. Br J Haematol 70:345-55, 1988.
Pubmed reference: 3207628 .
1986 Fogh,J.M.: :
[Haemophilia A in German Shepherd dogs in Denmark] Dansk Veterinaertidsskrift 69:938-940, 1986.
1986 Hein,H.: :
Haemophilia A in German shepherd dogs. Vet Rec 118:619, 1986.
Pubmed reference: 3727330 .
1986 Pijnappels,M.I.,Briët,E.,vanderZwet,G.T.,Huisden,R.,vanTilburg,N.H.,Eulderink,F.: :
Evaluation of the cuticle bleeding time in canine haemophilia A. Thromb Haemost 55:70-3, 1986.
Pubmed reference: 3085267 .
1985 Brinkhous,K.M.,Sandberg,H.,Garris,J.B.,Mattsson,C.,Palm,M.,Griggs,T.,Read,M.S.: :
Purified human factor VIII procoagulant protein: comparative hemostatic response after infusions into hemophilic and von Willebrand disease dogs. Proc Natl Acad Sci U S A 82:8752-6, 1985.
Pubmed reference: 3936044 .
1982 Dodds,W.J.: :
An effective mass-screening program for animal models of the inherited bleeding disorders. Prog Clin Biol Res 94:117-32, 1982.
Pubmed reference: 6981819 .
1982 Giles,A.R.,Tinlin,S.,Greenwood,R.: :
A canine model of hemophilic (factor VIII:C deficiency) bleeding. Blood 60:727-30, 1982.
Pubmed reference: 6809076 .
1980 Spurling,N.W.: :
Hereditary disorders of haemostasis in dogs: a critical review of the literature Veterinary Bulletin 50:151-173, 1980.
1977 Gentry,P.A.,Johnstone,I.B.,Sanford,S.E.: :
Diagnosis of classic hemophilia (Hemophilia A) in a standard Poodle Canadian Veterinary Journal 18:79-81, 1977.
1975 Aufderheide,W.M.,Skinner,S.F.,Kaneko,J.J.: :
Clearance of cryoprecipitated factor VIII in canine hemophilia A American Journal of Veterinary Research 36:367-370, 1975.
Pubmed reference: 1124873 .
1975 Slappendel,R.J.: :
Hemophilia A and hemophilia B in a family of French bulldogs Tijdschrift voor Diergeneeskunde 100:1075-1088, 1975.
Pubmed reference: 1209580 .
1974 Dodds,W.J.: :
Hereditary and acquired hemorrhagic disorders in animals. Prog Hemost Thromb 2:215-47, 1974.
Pubmed reference: 4604529 .
1973 Brinkhous,K.M.,Davis,P.D.,Graham,J.B.,Dodds,W.J.: :
Expression and linkage of genes for X-linked hemophilias A and B in the dog. Blood 41:577-85, 1973.
Pubmed reference: 4688873 .
1973 Hampton,J.W.,Buckner,R.G.,Gunn,C.G.,Miller,L.R.,Mayes,J.S.: :
Canine hemophilia in Beagles: genetics, site of factor VIII synthesis, and attempts at experimental therapy Haemophilia. Proceedings of the Seventh Congress of the World Federation of Haemophilia, May 17-20, 1971, Tehran, Iran :?, 1973.
1968 Davis,P.D.: :
Canine double heterozygotes for hemophilia A and B. Federation Proceedings 27:627, 1968.
1968 Norman,J.C.,Covelli,V.H.,Sise,H.S.: :
Transplantation of the spleen (Editorial) Annals of Internal Medicine 78:700-704, 1968.
1967 Pick,J.R.,Goyer,R.A.,Graham,J.B.: :
Subluxation on the carpus in dogs: a genetic defect on the X-chromosome closely linked to the locus for hemophilia A Federation Proceedings 26:358 only, 1967.
1965 White,J.M.,Holm,G.C.: :
Colony of Hemophilic Dogs. Science 150:1766, 1965.
Pubmed reference: 17841958 . DOI: 10.1126/science.150.3705.1766 .
1963 Brock,W.E.,Buckner,R.G.,Hampton,J.W.,Bird,R.M.,Wultz,C.E.: :
Canine hemophilia-establishment of a new colony Archives of Pathology 76:464-469, 1963.
Pubmed reference: 14054168 .
1957 Wagner,R.H.: :
Antihemophilic factor (AHF): plasma levels after administration of AHF preparations to haemophilic dogs Proceedings of the Society for Experimental Biology and Medicine 96:152-155, 1957.
Pubmed reference: 13485042 .
1955 Swanton,M.C.,Brinkhous,K.M.: :
Hemophilic arthropathy in dogs American Journal of Pathology 31:596-597, 1955.
1950 Brinkhous,K.M.,Graham,J.B.: :
Hemophilia in the female dog. Science 111:723-4, 1950.
Pubmed reference: 15431070 .
1949 Graham,J.B.,Buckwalter,J.A.,Hartley,L.J.,Brinkhous,K.M.: :
Canine hemophilia; observations on the course, the clotting anomaly, and the effect of blood transfusions. J Exp Med 90:97-111, 1949.
Pubmed reference: 18136192 .
1948 Hutt,F.B.,Rickard,C.G.,Field,R.A.: :
Sex-linked hemophilia in dogs Journal of Heredity 39:2-9, 1948.
1946 Field,R.A.,Rickard,C.G.,Hutt,F.B.: :
Hemophilia in a family of dogs. Cornell Veterinarian 36:285, 1946.
1938 Merkens,J.: :
Haemophile bij Honden Journal Ned. Ind. Bladen v Diergeneesk en Dierant. 50:149-151, 1938.