The detail information of Polyneuropathy, NDRG1-related
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Year key mutation first reported: 2010

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB5 Alaskan Malamute 63.5 cm (male), 58.4 cm (female) 38.6 kg (male), 34 kg (female) United States
CB122 Greyhound 71.1-76.2 cm (male), 68.6-71.1 cm (female) 29.5-31.8 kg (male), 27.2-29.5 kg (female) United Kingdom, Middle East
Associated Gene
Symbol Description Species Position Other Links
NDRG1 N-myc downstream regulated 1 Canis lupus familiaris Chr13 : 30105421 - 30048859 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Skedsmo,F.S.,Espenes,A.,Tranulis,M.A.,Matiasek,K.,Gunnes,G.,Bjerkås,I.,Moe,L.,Røed,S.S.,Berendt,M.,Fredholm,M.,Rohdin,C.,Shelton,G.D.,Bruheim,P.,Stafsnes,M.H.,Bartosova,Z.,Hermansen,L.C.,Stigen,Ø.,Jäderlund,K.H.: :
Impaired NDRG1 functions in Schwann cells cause demyelinating neuropathy in a dog model of Charcot-Marie-Tooth type 4D. Neuromuscul Disord :, 2020.
Pubmed reference: 33334662 . DOI: 10.1016/j.nmd.2020.11.010 .
2017 Jäderlund,K.H.,Rohdin,C.,Berendt,M.,Stigen,Ø.,Fredholm,M.,Espenes,A.,Bjerkås,I.,Moe,L.: :
Re-emergence of hereditary polyneuropathy in Scandinavian Alaskan malamute dogs-old enemy or new entity? A case series. Acta Vet Scand 59:26, 2017.
Pubmed reference: 28464941 . DOI: 10.1186/s13028-017-0295-y .
2013 Bruun,C.S.,Jäderlund,K.H.,Berendt,M.,Jensen,K.B.,Spodsberg,E.H.,Gredal,H.,Shelton,G.D.,Mickelson,J.R.,Minor,K.M.,Lohi,H.,Bjerkås,I.,Stigen,O.,Espenes,A.,Rohdin,C.,Edlund,R.,Ohlsson,J.,Cizinauskas,S.,Leifsson,P.S.,Drögemüller,C.,Moe,L.,Cirera,S.,Fredholm,M.: :
A Gly98Val mutation in the N-Myc Downstream Regulated Gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy. PLoS One 8:e54547, 2013.
Pubmed reference: 23393557 . DOI: 10.1371/journal.pone.0054547 .
2012 Rentmeister,K.,Bilzer,T.,Petri,S.,Schanen,G.,Fehr,M.,Distl,O.,Tipold,A.: :
Hereditary polyneuropathy in the Alaskan Malamute. Tierarztl Prax Ausg K Kleintiere Heimtiere 40:26-34, 2012.
Pubmed reference: 22331326 .
2010 Drögemüller,C.,Becker,D.,Kessler,B.,Kemter,E.,Tetens,J.,Jurina,K.,Jaderlund,KH.,Flagstad,A.,Perloski,M.,Lindblad-Toh,K.,Matiasek,K.: :
A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy. PLoS One 5:e11258, 2010.
Pubmed reference: 20582309 . DOI: 10.1371/journal.pone.0011258 .
2009 Wakshlag,JJ.,deLahunta,A.: :
Hereditary encephalomyelopathy and polyneuropathy in an Alaskan husky. J Small Anim Pract 50:670-4, 2009.
Pubmed reference: 19954445 . DOI: 10.1111/j.1748-5827.2009.00857.x .
1997 Braund,K.G.,Shores,A.,Lowrie,C.T.,Steinberg,H.S.,Moore,M.P.,Bagley,R.S.,Steiss,J.E.: :
Idiopathic polyneuropathy in Alaskan Malamutes Journal of Veterinary Internal Medicine 11:243-249, 1997.
Pubmed reference: 9298480 .