The detail information of Intervertebral disc disease, type I
OMIA Basic Information

Possible human homologues (MIM numbers): -

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Dominant

Considered a defect: yes

Year key mutation first reported: 2017

Species-specific name: Intervertebral disc disease

Species-specific symbol: IVDD

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB83 Dachshund 20.3-22.9 cm (standard), 12.7-15.2 cm (miniature) 7.3-14.5 kg (standard), 5 kg & under (miniature) Germany
Associated Gene
Symbol Description Species Position Other Links
FGF4 retrogene in CFA12 - Canis lupus familiaris Chr- : - - - Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2020 Batcher,K.,Dickinson,P.,Maciejczyk,K.,Brzeski,K.,Rasouliha,S.H.,Letko,A.,Drögemüller,C.,Leeb,T.,Bannasch,D.: :
Multiple <i>FGF4</i> Retrocopies Recently Derived within Canids. Genes (Basel) 11:, 2020.
Pubmed reference: 32717834 . DOI: 10.3390/genes11080839 .
2020 Bruun,C.S.,Bruun,C.,Marx,T.,Proschowsky,H.F.,Fredholm,M.: :
Breeding schemes for intervertebral disc disease in dachshunds: Is disc calcification score preferable to genotyping of the FGF4 retrogene insertion on CFA12? Canine Med Genet 7:18, 2020.
Pubmed reference: 33292664 . DOI: 10.1186/s40575-020-00096-6 .
2020 Fenn,J.,Olby,N.J.: :
Classification of Intervertebral Disc Disease. Front Vet Sci 7:579025, 2020.
Pubmed reference: 33134360 . DOI: 10.3389/fvets.2020.579025 .
2019 Batcher,K.,Dickinson,P.,Giuffrida,M.,Sturges,B.,Vernau,K.,Knipe,M.,Rasouliha,S.H.,Drögemüller,C.,Leeb,T.,Maciejczyk,K.,Jenkins,C.A.,Mellersh,C.,Bannasch,D.: :
Phenotypic Effects of <i>FGF4</i> Retrogenes on Intervertebral Disc Disease in Dogs. Genes (Basel) 10:, 2019.
Pubmed reference: 31181696 . DOI: 10.3390/genes10060435 .
2019 Murphy,B.G.,Dickinson,P.,Marcellin-Little,D.J.,Batcher,K.,Raverty,S.,Bannasch,D.: :
Pathologic Features of the Intervertebral Disc in Young Nova Scotia Duck Tolling Retrievers Confirms Chondrodystrophy Degenerative Phenotype Associated With Genotype. Vet Pathol :300985819868731, 2019.
Pubmed reference: 31526126 . DOI: 10.1177/0300985819868731 .
2017 Brown,E.A.,Dickinson,P.J.,Mansour,T.,Sturges,B.K.,Aguilar,M.,Young,A.E.,Korff,C.,Lind,J.,Ettinger,C.L.,Varon,S.,Pollard,R.,Brown,C.T.,Raudsepp,T.,Bannasch,D.L.: :
FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs. Proc Natl Acad Sci U S A 114:11476-11481, 2017.
Pubmed reference: 29073074 . DOI: 10.1073/pnas.1709082114 .
2016 Dugat,D.R.,Bartels,K.E.,Payton,M.E.: :
Recurrence of disk herniation following percutaneous laser disk ablation in dogs with a history of thoracolumbar intervertebral disk herniation: 303 cases (1994-2011). J Am Vet Med Assoc 249:1393-1400, 2016.
Pubmed reference: 27901458 . DOI: 10.2460/javma.249.12.1393 .
2016 Packer,R.M.,Seath,I.J.,O'Neill,D.G.,DeDecker,S.,Volk,H.A.: :
DachsLife 2015: an investigation of lifestyle associations with the risk of intervertebral disc disease in Dachshunds. Canine Genet Epidemiol 3:8, 2016.
Pubmed reference: 27826450 . DOI: 10.1186/s40575-016-0039-8 .
2016 Shi,Z.Y.,Gu,T.,Zhang,C.,Wang,D.L.,He,Q.,Ruan,D.K.: :
Computed tomography-guided nucleus pulposus biopsy for canine intervertebral disc degeneration preparation: a radiology and histology study. Spine J 16:252-8, 2016.
Pubmed reference: 24845965 . DOI: 10.1016/j.spinee.2013.11.061 .
2015 Hakozaki,T.,Iwata,M.,Kanno,N.,Harada,Y.,Yogo,T.,Tagawa,M.,Hara,Y.: :
Cervical intervertebral disk herniation in chondrodystrophoid and nonchondrodystrophoid small-breed dogs: 187 cases (1993-2013). J Am Vet Med Assoc 247:1408-11, 2015.
Pubmed reference: 26642135 . DOI: 10.2460/javma.247.12.1408 .
2015 Lappalainen,A.K.,Mäki,K.,Laitinen-Vapaavuori,O.: :
Estimate of heritability and genetic trend of intervertebral disc calcification in Dachshunds in Finland. Acta Vet Scand 57:78, 2015.
Pubmed reference: 26597811 . DOI: 10.1186/s13028-015-0170-7 .
2015 Oberbauer,A.M.,Belanger,J.M.,Bellumori,T.,Bannasch,D.L.,Famula,T.R.: :
Ten inherited disorders in purebred dogs by functional breed groupings. Canine Genet Epidemiol 2:9, 2015.
Pubmed reference: 26401337 . DOI: 10.1186/s40575-015-0021-x .
2015 Rosenblatt,A.J.,Hill,P.B.,Davies,S.E.,Webster,N.S.,Lappalainen,A.K.,Bottema,C.D.,Caraguel,C.G.: :
Precision of spinal radiographs as a screening test for intervertebral disc calcification in Dachshunds. Prev Vet Med 122:164-73, 2015.
Pubmed reference: 26493589 . DOI: 10.1016/j.prevetmed.2015.09.015 .
2014 Lappalainen,A.K.,Vaittinen,E.,Junnila,J.,Laitinen-Vapaavuori,O.: :
Intervertebral disc disease in Dachshunds radiographically screened for intervertebral disc calcifications. Acta Vet Scand 56:89, 2014.
Pubmed reference: 25523328 . DOI: 10.1186/s13028-014-0089-4 .
2014 Rosenblatt,A.J.,Bottema,C.D.,Hill,P.B.: :
Radiographic scoring for intervertebral disc calcification in the Dachshund. Vet J :, 2014.
Pubmed reference: 24742872 . DOI: 10.1016/j.tvjl.2014.03.023 .
2013 Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013.
Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 .
2013 Jeffery,N.D.,Levine,J.M.,Olby,N.J.,Stein,V.M.: :
Intervertebral Disk Degeneration in Dogs: Consequences, Diagnosis, Treatment, and Future Directions. J Vet Intern Med :, 2013.
Pubmed reference: 24010573 . DOI: 10.1111/jvim.12183 .
2012 Bergknut,N.,Meij,B.P.,Hagman,R.,deNies,K.S.,Rutges,J.P.,Smolders,L.A.,Creemers,L.B.,Lagerstedt,A.S.,Hazewinkel,H.A.,Grinwis,G.C.: :
Intervertebral disc disease in dogs - Part 1: A new histological grading scheme for classification of intervertebral disc degeneration in dogs. Vet J :, 2012.
Pubmed reference: 22789628 . DOI: 10.1016/j.tvjl.2012.05.027 .
2012 Bergknut,N.,Smolders,L.A.,Grinwis,G.C.,Hagman,R.,Lagerstedt,A.S.,Hazewinkel,H.A.,Tryfonidou,M.A.,Meij,B.P.: :
Intervertebral disc degeneration in the dog. Part 1: Anatomy and physiology of the intervertebral disc and characteristics of intervertebral disc degeneration. Vet J :, 2012.
Pubmed reference: 23177522 . DOI: 10.1016/j.tvjl.2012.10.024 .
2012 Kranenburg,H.J.,Grinwis,G.C.,Bergknut,N.,Gahrmann,N.,Voorhout,G.,Hazewinkel,H.A.,Meij,B.P.: :
Intervertebral disc disease in dogs - Part 2: Comparison of clinical, magnetic resonance imaging, and histological findings in 74 surgically treated dogs. Vet J :, 2012.
Pubmed reference: 22795604 . DOI: 10.1016/j.tvjl.2012.06.001 .
2012 Mogensen,M.S.,Scheibye-Alsing,K.,Karlskov-Mortensen,P.,Proschowsky,H.F.,Jensen,V.F.,Bak,M.,Tommerup,N.,Kadarmideen,H.N.,Fredholm,M.: :
Validation of genome-wide intervertebral disk calcification associations in dachshund and further investigation of the chromosome 12 susceptibility locus. Front Genet 3:225, 2012.
Pubmed reference: 23125846 . DOI: 10.3389/fgene.2012.00225 .
2012 Nagano,S.,Fujiki,M.,Tokunaga,S.,Misumi,K.: :
Analysis of cartilage oligomeric matrix protein and matrix metalloproteinase-9 in cerebrospinal fluid of miniature dachshund with intervertebral disc herniation. Res Vet Sci 93:1487-92, 2012.
Pubmed reference: 22440362 . DOI: 10.1016/j.rvsc.2012.02.014 .
2012 Smolders,L.A.,Bergknut,N.,Grinwis,G.C.,Hagman,R.,Lagerstedt,A.S.,Hazewinkel,H.A.,Tryfonidou,M.A.,Meij,B.P.: :
Intervertebral disc degeneration in the dog. Part 2: Chondrodystrophic and non-chondrodystrophic breeds. Vet J :, 2012.
Pubmed reference: 23154070 . DOI: 10.1016/j.tvjl.2012.10.011 .
2011 Mogensen,M.S.,Karlskov-Mortensen,P.,Proschowsky,H.F.,Lingaas,F.,Lappalainen,A.,Lohi,H.,Jensen,V.F.,Fredholm,M.: :
Genome-wide association study in dachshund: identification of a major locus affecting intervertebral disc calcification. J Hered :S81-6, 2011.
Pubmed reference: 21846751 . DOI: 10.1093/jhered/esr021 .
2001 Jensen,V.F.: :
Asymptomatic radiographic disappearance of calcified intervertebral disc material in the Dachshund. Vet Radiol Ultrasound 42:141-8, 2001.
Pubmed reference: 11327362 .
2000 Jensen,V.F.,Christensen,K.A.: :
Inheritance of disc calcification in the dachshund. J Vet Med A Physiol Pathol Clin Med 47:331-40, 2000.
Pubmed reference: 11008442 .
2000 Jensen,V.F.,Ersbøll,A.K.: :
Mechanical factors affecting the occurrence of intervertebral disc calcification in the dachshund--a population study. J Vet Med A Physiol Pathol Clin Med 47:283-96, 2000.
Pubmed reference: 10932525 .
1975 Braund,K.G.,Ghosh,P.,Taylor,T.K.F.,Larsen,L.H.: :
Morphological studies of the canine intervertebral disc: the assignment of the Beagle to the achondroplastic classification Research in Veterinary Science 19:167-172, 1975.
Pubmed reference: 1166121 .
1952 Hansen,H.J.: :
A pathologic-anatomical study on disc degeneration in dog, with special reference to the so-called enchondrosis intervertebralis. Acta Orthop Scand Suppl 11:1-117, 1952.
Pubmed reference: 14923291 .
1951 Hansen,H.J.: :
A pathologic-anatomical interpretation of disc degeneration in dogs. Acta Orthop Scand 20:280-93, 1951.
Pubmed reference: 14894198 .