The detail information of Trapped Neutrophil Syndrome
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: yes

Year key mutation first reported: 2011

Species-specific name: -

Species-specific symbol: TNS

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
Symbol Description Species Position Other Links
VPS13B vacuolar protein sorting 13 homolog B (yeast) Canis lupus familiaris Chr13 : 1253509 - 1988060 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 Soh,P.X.Y.,Hsu,W.T.,Khatkar,M.S.,Williamson,P.: :
Evaluation of genetic diversity and management of disease in Border Collie dogs. Sci Rep 11:6243, 2021.
Pubmed reference: 33737533 . DOI: 10.1038/s41598-021-85262-x .
2016 Mizukami,K.,Yabuki,A.,Kohyama,M.,Kushida,K.,Rahman,M.M.,Uddin,M.M.,Sawa,M.,Yamato,O.: :
Molecular prevalence of multiple genetic disorders in Border collies in Japan and recommendations for genetic counselling. Vet J 214:21-3, 2016.
Pubmed reference: 27387721 . DOI: 10.1016/j.tvjl.2016.05.004 .
2013 Mizukami,K.,Yabuki,A.,Kawamichi,T.,Chang,H.S.,Rahman,M.M.,Uddin,M.M.,Kohyama,M.,Yamato,O.: :
Real-time PCR genotyping assay for canine trapped neutrophil syndrome and high frequency of the mutant allele in Border collies. Vet J 195:260-1, 2013.
Pubmed reference: 22795605 . DOI: 10.1016/j.tvjl.2012.06.014 .
2012 Mizukami,K.,Shoubudani,T.,Nishimoto,S.,Kawamura,R.,Yabuki,A.,Yamato,O.: :
Trapped neutrophil syndrome in a Border Collie dog: clinical, clinico-pathologic, and molecular findings. J Vet Med Sci 74:797-800, 2012.
Pubmed reference: 22240985 .
2011 Shearman,JR.,Wilton,AN.: :
A canine model of cohen syndrome: trapped neutrophil syndrome. BMC Genomics 12:258, 2011.
Pubmed reference: 21605373 . DOI: 10.1186/1471-2164-12-258 .
2007 Shearman,JR.,Wilton,AN.: :
Elimination of neutrophil elastase and the genes for [corrected] adaptor protein complex 3 subunits [corrected] as the cause of trapped neutrophil syndrome in Border collies. Anim Genet 38:188-9, 2007.
Pubmed reference: 17302793 . DOI: 10.1111/j.1365-2052.2007.01565.x .
2006 Shearman,JR.,Zhang,QY.,Wilton,AN.: :
Exclusion of CXCR4 as the cause of trapped neutrophil syndrome in Border Collies using five microsatellites on canine chromosome 19. Anim Genet 37:89, 2006.
Pubmed reference: 16441310 . DOI: 10.1111/j.1365-2052.2005.01413.x .
1996 Allan,F.J.,Thompson,K.G.,Jones,B.R.,Burbidge,H.M.,Mckinley,R.L.: :
Neutropenia with a probable hereditary basis in border collies New Zealand Veterinary Journal 44:67-72, 1996.
Pubmed reference: 16031897 . DOI: 10.1080/00480169.1996.35937 .