Possible human homologues (MIM numbers):
Mendelian trait/disorder: yes
Mode of inheritance: Autosomal Recessive
Considered a defect: no
Year key mutation first reported: 2002
Species-specific name: This is the classic B (Brown) locus described by Little (1957)
Species-specific symbol: B locus
More detail information can see in
Symbol | Description | Species | Position | Other Links |
---|---|---|---|---|
TYRP1 | tyrosinase-related protein 1 | Canis lupus familiaris | Chr11 : 34222689 - 34240515 | Homologene, Ensembl, NCBI gene |
2021 |
VanBuren,S.L.,Mickelson,J.R.,Minor,K.M.: :
A novel TYRP1 mutation associated with brown coat color in Siberian huskies. Anim Genet :, 2021. Pubmed reference: 33421162 . DOI: 10.1111/age.13037 . |
2019 |
Wright,H.E.,Schofield,E.,Mellersh,C.S.,Burmeister,L.M.,Wright,H.E.,Schofield,E.,Mellersh,C.S.,Burmeister,L.M.: :
A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers. Anim Genet :, 2019. Pubmed reference: 31468558 . DOI: 10.1111/age.12839 . |
2019 |
vanRooy,D.,Wade,C.M.: :
Association between coat colour and the behaviour of Australian Labrador retrievers. Canine Genet Epidemiol 6:10, 2019. Pubmed reference: 31798910 . DOI: 10.1186/s40575-019-0078-z . |
2018 |
Jancuskova,T.,Langevin,M.,Pekova,S.: :
TYRP1:c.555T>G is a recurrent mutation found in Australian Shepherd and Miniature American Shepherd dogs. Anim Genet :, 2018. Pubmed reference: 30109695 . DOI: 10.1111/age.12709 . |
2017 |
HrckovaTurnova,E.,Majchrakova,Z.,Bielikova,M.,Soltys,K.,Turna,J.,Dudas,A.: :
A novel mutation in the TYRP1 gene associated with brown coat colour in the Australian Shepherd Dog Breed. Anim Genet 48:626, 2017. Pubmed reference: 28497851 . DOI: 10.1111/age.12563 . |
2017 |
Letko,A.,Drögemüller,C.: :
Two brown coat colour-associated TYRP1 variants (b(c) and b(d) ) occur in Leonberger dogs. Anim Genet 48:732-733, 2017. Pubmed reference: 28983931 . DOI: 10.1111/age.12612 . |
2015 |
Monteagudo,L.V.,Tejedor,M.T.: :
The b(c) allele of TYRP1 is causative for the recessive brown (liver) colour in German Shepherd dogs. Anim Genet 46:588-9, 2015. Pubmed reference: 26370740 . DOI: 10.1111/age.12337 . |
2012 |
Schmutz,S.M.,Melekhovets,Y.: :
Coat color DNA testing in dogs: theory meets practice. Mol Cell Probes 26:238-42, 2012. Pubmed reference: 22507852 . DOI: 10.1016/j.mcp.2012.03.009 . |
2011 |
Gerding,WM.,Schreiber,S.,Dekomien,G.,Epplen,JT.: :
Tracing the origin of 'blue Weimaraner' dogs by molecular genetics. J Anim Breed Genet 128:153-60, 2011. Pubmed reference: 21385230 . DOI: 10.1111/j.1439-0388.2010.00888.x . |
2005 |
Cargill,E.J.,Famula,T.R.,Schnabel,R.D.,Strain,G.M.,Murphy,K.E.: :
The color of a Dalmatian's spots: linkage evidence to support the TYRP1 gene. BMC Vet Res 1:1, 2005. Pubmed reference: 16045797 . DOI: 10.1186/1746-6148-1-1 . |
2002 |
Schmutz,S.M.,Berryere,T.G.,Goldfinch,A.D.: :
TYRP1 and MC1R genotypes and their effects on coat color in dogs Mammalian Genome 13:380-387, 2002. Pubmed reference: 12140685 . DOI: 10.1007/s00335-001-2147-2 . |
1957 |
Little,C.C.: :
The Inheritance of Coat Color in Dogs Comstock Publishing Associates, Cornell University Press, Ithaca, NY :, 1957. |