The detail information of Coat colour, brown, TYRP1-related
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal Recessive

Considered a defect: no

Year key mutation first reported: 2002

Species-specific name: This is the classic B (Brown) locus described by Little (1957)

Species-specific symbol: B locus

More detail information can see in

Associated Breeds
There are associated breeds.
Associated Gene
Symbol Description Species Position Other Links
TYRP1 tyrosinase-related protein 1 Canis lupus familiaris Chr11 : 34222689 - 34240515 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2021 VanBuren,S.L.,Mickelson,J.R.,Minor,K.M.: :
A novel TYRP1 mutation associated with brown coat color in Siberian huskies. Anim Genet :, 2021.
Pubmed reference: 33421162 . DOI: 10.1111/age.13037 .
2019 Wright,H.E.,Schofield,E.,Mellersh,C.S.,Burmeister,L.M.,Wright,H.E.,Schofield,E.,Mellersh,C.S.,Burmeister,L.M.: :
A novel TYRP1 variant is associated with liver and tan coat colour in Lancashire Heelers. Anim Genet :, 2019.
Pubmed reference: 31468558 . DOI: 10.1111/age.12839 .
2019 vanRooy,D.,Wade,C.M.: :
Association between coat colour and the behaviour of Australian Labrador retrievers. Canine Genet Epidemiol 6:10, 2019.
Pubmed reference: 31798910 . DOI: 10.1186/s40575-019-0078-z .
2018 Jancuskova,T.,Langevin,M.,Pekova,S.: :
TYRP1:c.555T>G is a recurrent mutation found in Australian Shepherd and Miniature American Shepherd dogs. Anim Genet :, 2018.
Pubmed reference: 30109695 . DOI: 10.1111/age.12709 .
2017 HrckovaTurnova,E.,Majchrakova,Z.,Bielikova,M.,Soltys,K.,Turna,J.,Dudas,A.: :
A novel mutation in the TYRP1 gene associated with brown coat colour in the Australian Shepherd Dog Breed. Anim Genet 48:626, 2017.
Pubmed reference: 28497851 . DOI: 10.1111/age.12563 .
2017 Letko,A.,Drögemüller,C.: :
Two brown coat colour-associated TYRP1 variants (b(c) and b(d) ) occur in Leonberger dogs. Anim Genet 48:732-733, 2017.
Pubmed reference: 28983931 . DOI: 10.1111/age.12612 .
2015 Monteagudo,L.V.,Tejedor,M.T.: :
The b(c) allele of TYRP1 is causative for the recessive brown (liver) colour in German Shepherd dogs. Anim Genet 46:588-9, 2015.
Pubmed reference: 26370740 . DOI: 10.1111/age.12337 .
2012 Schmutz,S.M.,Melekhovets,Y.: :
Coat color DNA testing in dogs: theory meets practice. Mol Cell Probes 26:238-42, 2012.
Pubmed reference: 22507852 . DOI: 10.1016/j.mcp.2012.03.009 .
2011 Gerding,WM.,Schreiber,S.,Dekomien,G.,Epplen,JT.: :
Tracing the origin of 'blue Weimaraner' dogs by molecular genetics. J Anim Breed Genet 128:153-60, 2011.
Pubmed reference: 21385230 . DOI: 10.1111/j.1439-0388.2010.00888.x .
2005 Cargill,E.J.,Famula,T.R.,Schnabel,R.D.,Strain,G.M.,Murphy,K.E.: :
The color of a Dalmatian's spots: linkage evidence to support the TYRP1 gene. BMC Vet Res 1:1, 2005.
Pubmed reference: 16045797 . DOI: 10.1186/1746-6148-1-1 .
2002 Schmutz,S.M.,Berryere,T.G.,Goldfinch,A.D.: :
TYRP1 and MC1R genotypes and their effects on coat color in dogs Mammalian Genome 13:380-387, 2002.
Pubmed reference: 12140685 . DOI: 10.1007/s00335-001-2147-2 .
1957 Little,C.C.: :
The Inheritance of Coat Color in Dogs Comstock Publishing Associates, Cornell University Press, Ithaca, NY :, 1957.