The detail information of Von Willebrand disease III
OMIA Basic Information

Possible human homologues (MIM numbers):

Mendelian trait/disorder: yes

Mode of inheritance: Autosomal

Considered a defect: yes

Year key mutation first reported: 1998

Species-specific name: -

Species-specific symbol: -

More detail information can see in

Associated Breeds
iDog Breed Number Breed Name Personality Height Weight History Breed Source
CB214 Scottish Terrier 25.4 cm 8.6-10 kg (male), 8.2-9.5 kg (female) United Kingdom (Scotland)
CB216 Shetland Shepherd Dog 33-40.6 cm 6.8-11.3 kg United Kingdom (Scotland)
Associated Gene
Symbol Description Species Position Other Links
VWF von Willebrand factor Canis lupus familiaris Chr27 : 39191850 - 39329540 Homologene, Ensembl, NCBI gene
References
Note: the references are listed in reverse chronological order (from the most recent year to the earliest year), and alphabetically by first author within a year.
2016 Nichols,T.C.,Hough,C.,Agersø,H.,Ezban,M.,Lillicrap,D.: :
Canine models of inherited bleeding disorders in the development of coagulation assays, novel protein replacement and gene therapies. J Thromb Haemost 14:894-905, 2016.
Pubmed reference: 26924758 . DOI: 10.1111/jth.13301 .
2012 Boudreaux,M.K.: :
Inherited platelet disorders. J Vet Emerg Crit Care (San Antonio) 22:30-41, 2012.
Pubmed reference: 22316339 . DOI: 10.1111/j.1476-4431.2011.00702.x .
2004 Pathak,EJ.: :
Type 3 von Willebrand's disease in a Shetland sheepdog. Can Vet J 45:685-7, 2004.
Pubmed reference: 15368744 .
2004 vanOost,BA.,Versteeg,SA.,Slappendel,RJ.: :
DNA testing for type III von Willebrand disease in Dutch Kooiker dogs. J Vet Intern Med 18:282-8, 2004.
Pubmed reference: 15188812 .
2000 Venta,P.J.,Li,J.P.,Yuzbasiyan-Gurkan,V.,Brewer,G.J.,Schall,W.D.: :
Mutation causing von Willebrand's disease in Scottish terriers Journal of Veterinary Internal Medicine 14:10-19, 2000.
Pubmed reference: 10668811 .
1999 Johnstone,I.B.: :
Plasma von Willebrand factor-collagen binding activity in normal dogs and in dogs with von Willebrand's disease Journal of Veterinary Diagnostic Investigation 11:308-313, 1999.
Pubmed reference: 10424644 .
1998 Rieger,M.,Schwarz,H.P.,Turecek,P.L.,Dorner,F.,Vanmourik,J.A.,Mannhalter,C.: :
Identification of mutations in the canine von Willebrand factor gene associated with type III von-Willebrand-disease Thrombosis and Haemostasis 80:332-337, 1998.
Pubmed reference: 9716162 .
1998 Slappendel,R.J.,Beijer,E.G.M.,Vanleeuwen,M.: :
Type III von-Willebrands-disease in Dutch Kooiker dogs Veterinary Quarterly 20:93-97, 1998.
Pubmed reference: 9684296 .
1998 Stokol,T.,Parry,B.W.: :
Efficacy of fresh-frozen plasma and cryoprecipitate in dogs with Von-Willebrands-disease or hemophilia a Journal of Veterinary Internal Medicine 12:84-92, 1998.
Pubmed reference: 9560764 .
1998 Venta,P.J.,Brewer,G.J.,Yuzbasiyan-Gurkan,V.,Schall,W.D.,Duffendeck,J.: :
Inventors; The Regents of the University of Michigan, assignee. DNA encoding canine von Willebrand factor and methods of use. United States patent US6074832A. 1998 Aug 11 :, 1998.
1993 Brooks,M.,Catalfamo,J.: :
Buccal Mucosa Bleeding Time Is Prolonged in Canine Models of Primary Hemostatic Disorders Thrombosis and Haemostasis 70:777-780, 1993.
Pubmed reference: 8128434 .
1993 Johnstone,I.B.,Norris,A.M.,Hirzer,L.: :
Type-III von Willebrand's Disease in Scottish Terriers - A Report of 2 Cases Canadian Veterinary Journal - Revue Veterinaire Canadienne 34:679-681, 1993.