Disease Description: Xanthinuria is a descriptive term for excess urinary excretion of xanthine.
Inherit Mode: -
Disease Symptom: -
Disease Cause: -
Disease Diagnose: -
Treat Method: Xanthine stone disease affects multiple organ systems. Further kidney complications include acute and chronic kidney failure. In addition, xanthinuria often leads to Urolithiasis.The stones can be removed surgically, but the disease tends to recur. High fluid intake is the key to therapy. Dehydration is to be avoided whenever possible. Since alkalinization of the urine has little affect upon the solubility of xanthine, it adds little to the therapeutic regimen. Allopurinol, an inhibitor of xanthine oxidase enzyme, is sometimes recommended to decrease urinary uric acid excretion. Allopurinol treatment must be accompanied by a low purine diet.Foods with high purine content such as liver, kidney, bacon, veal, venison, turkey should be avoided.
Breeder Advice: -
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Xanthinuria, generic | - | Autosomal Recessive | - |
2016 |
Furrow,E.,Tate,N.,Minor,K.,Mickelson,J.,Peterson,K.,Lulich,J.: :
2016 ACVIM Forum Research Report Program: Three diverse mutations underlying canine xanthine urolithiasis. J Vet Intern Med 30:1537, 2016. DOI: 10.1111/jvim.13963 . |
2013 |
Jacinto,A.M.,Mellanby,R.J.,Chandler,M.,Bommer,N.X.,Carruthers,H.,Fairbanks,L.D.,Gow,A.G.: :
Urine concentrations of xanthine, hypoxanthine and uric acid in UK Cavalier King Charles spaniels. J Small Anim Pract 54:395-8, 2013. Pubmed reference: 23859747 . DOI: 10.1111/jsap.12106 . |
1998 |
Flegel,T.,Freistadt,R.,Haider,W.: :
Xanthine urolithiasis in a dachshund Veterinary Record 143:420-423, 1998. Pubmed reference: 9807792 . |
1997 |
Kucera,J.,Bulkova,T.,Rychla,R.,Jahn,P.: :
Bilateral xanthine nephrolithiasis in a dog Journal of Small Animal Practice 38:302-305, 1997. Pubmed reference: 9239633 . |
1997 |
Vanzuilen,C.D.,Nickel,R.F.,Vandijk,T.H.,Reijngoud,D.J.: :
Xanthinuria in a family of Cavalier King Charles spaniels Veterinary Quarterly 19:172-174, 1997. Pubmed reference: 9413115 . |
1996 |
Vanzuilen,C.D.,Nickel,R.F.,Reijngoud,D.J.: :
Xanthinuria (xanthine oxidase deficiency) in two Cavalier King Charles spaniels Veterinary Quarterly 18:S 24-S 25, 1996. |
1969 |
Delbarre,F.,Holtzer,A.,Auscher,C.: :
[Xanthine urinary lithiasis and xanthinuria in a dachshund. Deficiency, probably genetic, of the xanthine oxidase system]. C R Acad Hebd Seances Acad Sci D 269:1449-52, 1969. Pubmed reference: 4982510 . |