The detail information of Cleft lip
Basic Information
Disease Description: A condition where the two halves of the upper lip do not join together. Cleft palate and cleft lip are often seen together.
Inherit Mode: Cleft palate is believed to be an autosomal recessive trait in the Brittany spaniel.In the English and French bulldog, pointer, and shih tzu, the trait may be autosomal dominant with incomplete penetrance.
Disease Symptom: Affected pups are born with the condition. A minor defect will cause little or no problem, while a more severe defect will cause signs such as a chronic nasal discharge (that may include food), poor growth, aspiration pneumonia (from inhalation of food), or even death.
Disease Cause: -
Disease Diagnose: Your veterinarian will diagnose these conditions on physical examination.
Treat Method: Mild problems may not require any treatment, but more serious defects will require surgical repair to prevent complications such as aspiration pneumonia.
Breeder Advice: Affected animals should not be used for breeding, and it is prudent to avoid breeding their parents and siblings as well.
Disease Description Source: Link
Associated Diseases
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Cleft lip with or without cleft palate | - | Autosomal Recessive | ADAMTS20 | ||
| Cleft lip and palate | - | Autosomal Recessive | - | - |
Associated Breeds
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB11 | American Staffordshire Terrier | Confident, Smart, Good-natured | 18-19 inches (male), 17-18 inches (female) | 55-70 pounds (male), 40-55 pounds (female) | United States |
| CB25 | Bearded Collie | Bouncy, charismatic, friendly; smart, but also stubborn and independent | 53.3-55.9 cm (male), 50.8-53.3 cm (female) | 20.4-24.9 kg | United Kingdom (Scotland) |
| CB35 | Bichon Frise | Playful, curious, and peppy | 24.1-29.2 cm | 5.4-8.2 kg | Spain, Belgium |
| CB46 | Boston Terrier | Friendly, bright, amusing, and adaptable. | 38.1-43.2 cm | 4.5-11.3 kg | United States |
| CB47 | Bouvier des Flandres(Flanders Cattle Dog) | Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders | 62.2-69.9 cm (male), 59.7-67.3 cm (female) | 31.8-49.9 kg | Belgium |
| CB54 | Brittany | Bright, upbeat, fun-loving at home; a tireless, enthusiastic worker afield | 44.5-52.1 cm | 13.6-18.1 kg | France |
| CB58 | English Bulldog | Calm, courageous, and friendly; dignified but amusing. | 35.6-38.1 cm | 22.7 kg (male), 18.1 kg (female) | United Kingdom (England) |
| CB78 | Cocker Spaniel | Happy, smart, gentle | 36.8-39.4 cm (male), 34.3-36.8 cm (female) | 11.3-13.6 kg (male), 9.1-11.3 kg (female) | |
| CB83 | Dachshund | Friendly, Curious, Spunky | 20.3-22.9 cm (standard), 12.7-15.2 cm (miniature) | 7.3-14.5 kg (standard), 5 kg & under (miniature) | Germany |
| CB98 | English Toy Spaniel | Affectionate, Alert, Merry | 22.9-25.4 cm | 3.6-6.4 kg | England |
| CB106 | French Bulldog | Playful, smart, adaptable, and completely irresistible | 27.9-33 cm | under 12.7 kg | United Kingdom (England), France |
| CB107 | French Spaniel | Friendly, outgoing personality, well balanced and patient,eager to please, can be trained easily | France | ||
| CB110 | German Shepherd Dog | Smart, confident, courageous, and steady; a true dog lover's dog | 61-66 cm (male), 55.9-61 cm (female) | 29.5-40.8 kg (male), 22.7-31.8 kg (female) | Germany |
| CB111 | German Short-Haired Pointer | Friendly, smart, willing to please | 58.4-63.5 cm (male), 53.3-58.4 cm (female) | 24.9-31.8 kg (male), 20.4-27.2 kg (female) | Germany |
| CB147 | Labrador Retriever | Friendly and outgoing, Labs play well with others | 57.2-62.2 cm (male), 54.6-59.7 cm (female) | 29.5-36.3 kg (male), 24.9-31.8 kg (female) | Canada, United Kingdom (England) |
| CB161 | Miniature Schnauzer | Friendly, smart, obedient | 30.5-35.6 cm | 5-9.1 kg | Germany |
| CB178 | Pekingese | Affectionate, loyal, regal in manner | 15.2-22.9 cm | up to 6.4 kg | China |
| CB185 | English Pointer | Even-tempered, alert, hardworking, and loyal; a peerless hunting partner | 63.5-71.1 cm (male), 58.4-66 cm (female) | 24.9-34 kg (male), 20.4-29.5 kg (female) | United Kingdom (England) |
| CB197 | Hungarian Puli | Loyal, smart, home-loving; strong-willed but trainable | 43.2 cm (male), 40.6 cm (female) | 11.3-15.9 kg | Hungary |
| CB218 | Shih Tzu(Chrysanthemum Dog) | Outgoing, affectionate, playful and charming | 20.3-27.9 cm | 4.1-7.3 kg | China |
| CB219 | Kochi Ken(Shikoku) | Cautious and brave with good judgment,loyal to its master. | Japan | ||
| CB265 | American Pit Bull Terrier | Strength, confidence, and zest for life,eager to please and brimming over with enthusiasm,excellent family companions | 45.7-53.3 cm (male), 43.2 to 50.8 cm (female) | 15.9-27.2 kg (male), 13.6-22.7 kg (female) | United States |
References
| 2019 |
Roman,N.,Carney,P.C.,Fiani,N.,Peralta,S.: :
Incidence patterns of orofacial clefts in purebred dogs. PLoS One 14:e0224574, 2019. Pubmed reference: 31682628 . DOI: 10.1371/journal.pone.0224574 . |
| 2019 |
Roman,N.,Carney,P.C.,Fiani,N.,Peralta,S.: :
Incidence patterns of orofacial clefts in purebred dogs. PLoS One 14:e0224574, 2019. Pubmed reference: 31682628 . DOI: 10.1371/journal.pone.0224574 . |
| 2017 |
Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: :
Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017. Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 . |
| 2017 |
Peralta,S.,Fiani,N.,Kan-Rohrer,K.H.,Verstraete,F.J.M.: :
Morphological evaluation of clefts of the lip, palate, or both in dogs. Am J Vet Res 78:926-933, 2017. Pubmed reference: 28738009 . DOI: 10.2460/ajvr.78.8.926 . |
| 2015 |
Wolf,Z.T.,Brand,H.A.,Shaffer,J.R.,Leslie,E.J.,Arzi,B.,Willet,C.E.,Cox,T.C.,McHenry,T.,Narayan,N.,Feingold,E.,Wang,X.,Sliskovic,S.,Karmi,N.,Safra,N.,Sanchez,C.,Deleyiannis,F.W.,Murray,J.C.,Wade,C.M.,Marazita,M.L.,Bannasch,D.L.: :
Genome-wide association studies in dogs and humans identify ADAMTS20 as a risk variant for cleft lip and palate. PLoS Genet 11:e1005059, 2015. Pubmed reference: 25798845 . DOI: 10.1371/journal.pgen.1005059 . |
| 2011 |
Moura,E.,Cirio,S.M.,Pimpão,C.T.: :
Non-Syndromic Cleft Lip and Palate in Boxer Dogs: Evidence of Monogenic Autosomal Recessive Inheritance. Cleft Palate Craniofac J :, 2011. Pubmed reference: 21806339 . DOI: 10.1597/11-110 . |
| 2009 |
Kemp,C.,Thiele,H.,Dankof,A.,Schmidt,G.,Lauster,C.,Fernahl,G.,Lauster,R.: :
Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs. Cleft Palate Craniofac J 46:81-8, 2009. Pubmed reference: 19115787 . DOI: 10.1597/06-229.1 . |
| 2009 |
Kemp,C.,Thiele,H.,Dankof,A.,Schmidt,G.,Lauster,C.,Fernahl,G.,Lauster,R.: :
Cleft lip and/or palate with monogenic autosomal recessive transmission in Pyrenees shepherd dogs. Cleft Palate Craniofac J 46:81-8, 2009. Pubmed reference: 19115787 . DOI: 10.1597/06-229.1 . |
| 1972 |
Edmonds,L.,Stewart,R.W.,Selby,L.: :
Cleft lip and palate in dogs (Boxer breed): a preliminary report Carnivore Genetics Newsletter 9:204-209, 1972. |
| 1971 |
Sherwood,B.F.,Vakilzadeh,J.,Lemay,J.C.: :
Observations on the pathology in a colony of cleft palate and cleft lip dogs. Cleft Palate J 8:56-60, 1971. Pubmed reference: 5278761 . |
| 1968 |
Jurkiewicz,M.J.,Bryant,D.L.: :
Cleft lip and palate in dogs: a progress report. Cleft Palate J 5:30-6, 1968. Pubmed reference: 4383842 . |
| 1965 |
Jurkiewicz,M.J.: :
A genetic study of cleft lip and palate in dogs. Surg Forum 16:472-3, 1965. Pubmed reference: 5835234 . |
| 1964 |
Jurkiewicz,M.J.: :
Cleft lip and palate in dogs. Surg Forum 15:457-8, 1964. Pubmed reference: 14193444 . |
| 1961 |
Calnan,J.: :
The comparative anatomy of cleft lip and palate. I. Classification of cleft lip and palate in dogs. Br J Plast Surg 14:180-4, 1961. Pubmed reference: 13875838 . |
| 1961 |
Calnan,J.: :
The comparative anatomy of cleft lip and palate. I. Classification of cleft lip and palate in dogs. Br J Plast Surg 14:180-4, 1961. Pubmed reference: 13875838 . |
| 1958 |
SETTY,L.R.: :
Cleft lip and palate in the dog. J Am Vet Med Assoc 133:480, 1958. Pubmed reference: 13587379 . |