The detail information of X-linked muscular dystrophy
Basic Information

Disease Description: This inherited disease is caused by the lack of a single specific protein (dystrophin) which is normally found in muscle fibres. This disease is similar to Duchenne muscular dystrophy in humans.

Inherit Mode: The trait is sex-linked. This means that it is carried by females (clinically unaffected) whose male offspring will have a 50 per cent chance of developing the disease.

Disease Symptom: Unfortunately this is a severe, debilitating,progressive disease.It may progress rapidly or more slowly, and your dog will graduallybecome weaker and moredebilitated. There is no specific treatment or cure.

Disease Cause: -

Disease Diagnose: Your veterinarian will suspect this disease if youryoung pupexhibits a combination of the following clinical signs: generalizedmuscle weakness andatrophy, exercise intolerance, abnormal gait, excessive drooling,abnormal spinalcurvature. This diagnosis can be confirmed with blood tests (to lookfor elevated muscleenzymes), muscle biopsy, electromyography, and a neurological exam.

Treat Method: There is no cure or specific treatment for thisdisease. Some of theclinical signs may be treated with drugs, and physiotherapy may alsobe helpful.

Breeder Advice: Affected dogs should not be bred. The mother ofany affected dog isa carrier of the condition and should not be used for breedingpurposes.

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Muscular dystrophy, dysphagia-associated - - - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB30 Belgian Shepherd Dog Serious-minded, watchful, and very bright and trainable 61-66 cm (male), 55.9-61 cm (female) 24.9-34 kg (male), 20.4-27.2 kg (female) Belgium
CB111 German Short-Haired Pointer Friendly, smart, willing to please 58.4-63.5 cm (male), 53.3-58.4 cm (female) 24.9-31.8 kg (male), 20.4-27.2 kg (female) Germany
CB116 Golden Retriever Intelligent, friendly, and devoted. 58.4-61 cm (male), 54.6-57.2 cm (female) 29.5-34 kg (male), 24.9-29.5 kg (female) United Kingdom (Scotland)
CB132 Irish Terrier Bold, dashing, even reckless; stouthearted at work, tenderhearted at home 45.7 cm 12.2 kg (male), 11.3 kg (female) Ireland
CB161 Miniature Schnauzer Friendly, smart, obedient 30.5-35.6 cm 5-9.1 kg Germany
CB185 English Pointer Even-tempered, alert, hardworking, and loyal; a peerless hunting partner 63.5-71.1 cm (male), 58.4-66 cm (female) 24.9-34 kg (male), 20.4-29.5 kg (female) United Kingdom (England)
CB205 Rottweiler Reserved with strangers and affectionate and loyal with his family. 61-68.6 cm (male), 55.9-63.5 cm (female) 49.9-59 kg (male), 34.9-49.9 kg (female) Germany
CB210 Samoyed Gentle, adaptable, eager, friendly; conservative but never shy 53.3-59.7 cm (male), 48.3-53.3 cm (female) 20.4-29.5 kg (male), 15.9-22.7 kg (female) Russia
References
1999 Ackerman L. :
The Genetic Connection: A Guide to Health Problemsin Purebred Dogs AAHA Press,Lakewood, Colorado. pp.121-122
1995 Kornegay JN. :
Disorders of the skeletal muscles WB SaundersCo., Toronto. EJ Ettingerand EC Feldman (eds) Textbook of Veterinary Internal Medicine,pp.727-736
1994 Peeters,M.E.,Ubbink,G.J.: :
Dysphagia-Associated Muscular Dystrophy - A Familial Trait in the Bouvier Des Flandres Veterinary Record 134:444-446, 1994.
Pubmed reference: 8048216 .