Disease Description: This is a disorder of the small intestine that results from a sensitivity or intolerance to gluten, the protein part of wheat. There are many similarities to celiac disease in people, although the intestinal damage and clinical signs are less severe in dogs.
Inherit Mode: unknown
Disease Symptom: Signs of this disorder are usually apparent by about 6 months of age. Affected dogs fail to gain weight normally or start losing weight, and most develop chronic diarrhea.
Disease Cause: -
Disease Diagnose: There are various blood and fecal tests that will point your veterinarian to a diagnosis of gluten-sensitive enteropathy as a cause of your dog's diarrhea. The diagnosis is confirmed if the clinical problems resolve following the introduction of a gluten-free diet.
Treat Method: This disorder is treated by feeding a nutritionally balanced gluten-free diet to your dog for life. Typically the signs resolve within 4 to 6 weeks of the diet change.
Breeder Advice: Affected dogs should not be bred and until more is known about inheritance of this disorder, it is prudent to avoid breeding their parents and siblings as well.
Disease Description Source: Link
| Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
|---|---|---|---|---|---|
| Gluten-sensitive enteropathy | - | Autosomal Recessive | - |
| iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
|---|---|---|---|---|---|
| CB131 | Irish Setter | Outgoing, sweet-natured, active, and trainable | 68.6 cm (male), 63.5 cm (female) | 31.8 kg (male), 27.2 kg (female) | Ireland |
| 2019 |
Biagi,F.,Maimaris,S.,Vecchiato,C.G.,Costetti,M.,Biagi,G.: :
Gluten-sensitive enteropathy of the Irish Setter and similarities with human celiac disease. Minerva Gastroenterol Dietol :, 2019. Pubmed reference: 31820885 . DOI: 10.23736/S1121-421X.19.02648-5 . |
| 2016 |
Lowrie,M.,Hadjivassiliou,M.,Sanders,D.S.,Garden,O.A.: :
A presumptive case of gluten sensitivity in a border terrier: a multisystem disorder? Vet Rec :, 2016. Pubmed reference: 27784836 . DOI: 10.1136/vr.103910 . |
| 2000 |
Garden,O.A.,Pidduck,H.,Lakhani,K.H.,Walker,D.,Wood,J.L.N.,Batt,R.M.: :
Inheritance of gluten-sensitive enteropathy in Irish setters American Journal of Veterinary Research 61:462-468, 2000. Pubmed reference: 10772115 . |
| 1998 |
Manners,H.K.,Hart,C.A.,Getty,B.,Kelly,D.F.,Sorensen,S.H.,Batt,R.M.: :
Characterization of intestinal morphologic, biochemical, and ultrastructural features in gluten-sensitive irish setters during controlled oral gluten challenge exposure after weaning American Journal of Veterinary Research 59:1435-1440, 1998. Pubmed reference: 9829403 . |
| 1998 |
Manners,H.K.,Sorensen,S.H.,Embaye,H.,Odedra,R.M.,Batt,R.M.: :
Evidence for a compensatory increase in synthesis of brush border enzymes in the jejunum of irish setters with gluten-sensitive enteropathy American Journal of Veterinary Research 59:1392-1397, 1998. Pubmed reference: 9829395 . |
| 1998 |
Polvi,A.,Garden,O.A.,Houlston,R.S.,Maki,M.,Batt,R.M.,Partanen,J.: :
Genetic susceptibility to gluten sensitive enteropathy in Irish setter dogs is not linked to the major histocompatibility complex Tissue Antigens 52:543-549, 1998. Pubmed reference: 9894853 . |
| 1997 |
Pemberton,P.W.,Lobley,R.W.,Holmes,R.,Sorensen,S.H.,Batt,R.M.: :
Gluten-sensitive enteropathy in irish setter dogs - characterisation of jejunal microvillar membrane proteins by two-dimensional electrophoresis Research in Veterinary Science 62:191-193, 1997. Pubmed reference: 9243723 . |
| 1997 |
Polvi,A.,Garden,O.A.,Elwood,C.M.,Sorensen,S.H.,Batt,R.M.,Maki,M.,Partanen,J.: :
Canine major histocompatibility complex genes DQA and DQB in Irish Setter dogs Tissue Antigens 49:236-243, 1997. Pubmed reference: 9098930 . |
| 1996 |
Daminet,S.C.: :
Gluten-sensitive enteropathy in a family of Irish setters Canadian Veterinary Journal - Revue Veterinaire Canadienne 37:745-746, 1996. |