The detail information of Renal dysplasia
Basic Information

Disease Description: A condition where the kidneys form abnormally. Renal failure develops with protein loss in urine.

Inherit Mode: -

Disease Symptom: The early stage, called compensated renal insufficiency, is marked by excessive thirst and increased urination. When three-quarters of nephrons are gone, affected dogs are in renal failure. The kidneys can no longer filter toxins from the blood and the affected dogs are physically ill from the poison.The most severely affected dogs have problems by eight weeks of age. They die shortly thereafter. Mildly affected individuals may make it to six months of age before having problems.

Disease Cause: -

Disease Diagnose: -

Treat Method: Although some medications can relieve the pain and suffering of the dog, there is no cure for renal failure. Dialysis can be done, but it is expensive and typically buys only a small amount of time. A low-protein diet that is rich in specific amino acids and low in phosphates is the best nutritional approach for mildly affected individuals. Breeders should test their puppies as early as eight weeks.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Renal dysplasia - - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB89 Dogo Argentino Loyal, trustworthy,courageous 61-68.6 cm (male), 59.7-66 cm (female) 36.3-45.4 kg Argentina
CB162 Mountain Cur Intelligent, Strong-Willed 41-66cm 13.6-27.2kg United States
CB229 Spanish Mastiff Aloof, dignified, calm and intelligent Spain
References
2018 Dillard,K.J.,Hytönen,M.K.,Fischer,D.,Tanhuanpää,K.,Lehti,M.S.,Vainio-Siukola,K.,Sironen,A.,Anttila,M.: :
A splice site variant in INPP5E causes diffuse cystic renal dysplasia and hepatic fibrosis in dogs. PLoS One 13:e0204073, 2018.
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2015 Safra,N.,Hayward,L.J.,Aguilar,M.,Sacks,B.N.,Westropp,J.L.,Mohr,F.C.,Mellersh,C.S.,Bannasch,D.L.: :
DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves. PLoS One 10:e0133127, 2015.
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2014 Whiteley,M.H.: :
Allelic variation in the canine Cox-2 promoter causes hypermethylation of the canine Cox-2 promoter in clinical cases of renal dysplasia. Clin Epigenetics 6:7, 2014.
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2012 PLOSONEEditors: :
Expression of concern: Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs. PLoS One 7:e49703, 2012.
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2011 Whiteley,MH.,Bell,JS.,Rothman,DA.: :
Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs. PLoS One 6:e16684, 2011.
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2010 Bruder,MC.,Shoieb,AM.,Shirai,N.,Boucher,GG.,Brodie,TA.: :
Renal dysplasia in Beagle dogs: four cases. Toxicol Pathol 38:1051-7, 2010.
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2010 Seiler,GS.,Rhodes,J.,Cianciolo,R.,Casal,ML.: :
Ultrasonographic findings in Cairn Terriers with preclinical renal dysplasia. Vet Radiol Ultrasound 51:453-7, 2010.
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2003 Bovee,K.C.: :
Renal dysplasia in Shih Tzu dogs. Proceedings of the 28th Congress of the World Small Animal Veterinary Association :http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2003&PID=6602&O=Generic, 2003.
2001 Ohara,K.,Kobayashi,Y.,Tsuchiya,N.,Furuoka,H.,Matsui,T.: :
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2000 Hoppe,A.,Karlstam,E.: :
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1999 Olenick,C.L.: :
Congenital renal dysplasia and psychogenic polydipsia in a Bernese mountain dog Canadian Veterinary Journal - Revue Veterinaire Canadienne 40:425-426, 1999.
1998 Schulze,C.,Meyer,H.P.,Blok,A.L.,Schipper,K.,van,den,Ingh,T.S.G.A.M.: :
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1997 Felkai,C.,Voros,K.,Vrabely,T.,Vetesi,F.,Karsai,F.,Papp,L.: :
Ultrasonographic findings of renal dysplasia in Cocker Spaniels - eight cases Acta Veterinaria Hungarica 45:397-408, 1997.
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1997 Gross,T.L.: :
Calcinosis circumscripta and renal dysplasia in a dog Veterinary Dermatology 8:27-31, 1997.
1997 Miyamoto,T.,Wakizaka,S.,Matsuyama,S.,Baba,E.,Ohashi,F.,Kuwamura,M.,Yamate,J.,Kotani,T.: :
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1996 Lobetti,R.G.,Pearson,J.,Jimenez,M.: :
Renal dysplasia in a Rhodesian Ridgeback dog Journal of Small Animal Practice 37:552-555, 1996.
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1995 Kerlin,R.L.,Vanwinkle,T.J.: :
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1989 Murphy,M.G.: :
Renal Dysplasia in a Cavalier King Charles Spaniel Irish Veterinary Journal 42:96-97, 1989.