Disease Description: A condition where the kidneys form abnormally. Renal failure develops with protein loss in urine.
Inherit Mode: -
Disease Symptom: The early stage, called compensated renal insufficiency, is marked by excessive thirst and increased urination. When three-quarters of nephrons are gone, affected dogs are in renal failure. The kidneys can no longer filter toxins from the blood and the affected dogs are physically ill from the poison.The most severely affected dogs have problems by eight weeks of age. They die shortly thereafter. Mildly affected individuals may make it to six months of age before having problems.
Disease Cause: -
Disease Diagnose: -
Treat Method: Although some medications can relieve the pain and suffering of the dog, there is no cure for renal failure. Dialysis can be done, but it is expensive and typically buys only a small amount of time. A low-protein diet that is rich in specific amino acids and low in phosphates is the best nutritional approach for mildly affected individuals. Breeders should test their puppies as early as eight weeks.
Breeder Advice: -
Disease Description Source: Link
Disease Name | Other Name | Mode of inheritance | Link ID | Possible OMIM ID | Gene |
---|---|---|---|---|---|
Renal dysplasia | - | - | - |
iDog Breed Number | Breed Name | Personality | Height | Weight | Breed Source |
---|---|---|---|---|---|
CB89 | Dogo Argentino | Loyal, trustworthy,courageous | 61-68.6 cm (male), 59.7-66 cm (female) | 36.3-45.4 kg | Argentina |
CB162 | Mountain Cur | Intelligent, Strong-Willed | 41-66cm | 13.6-27.2kg | United States |
CB229 | Spanish Mastiff | Aloof, dignified, calm and intelligent | Spain |
2018 |
Dillard,K.J.,Hytönen,M.K.,Fischer,D.,Tanhuanpää,K.,Lehti,M.S.,Vainio-Siukola,K.,Sironen,A.,Anttila,M.: :
A splice site variant in INPP5E causes diffuse cystic renal dysplasia and hepatic fibrosis in dogs. PLoS One 13:e0204073, 2018. Pubmed reference: 30235266 . DOI: 10.1371/journal.pone.0204073 . |
2015 |
Safra,N.,Hayward,L.J.,Aguilar,M.,Sacks,B.N.,Westropp,J.L.,Mohr,F.C.,Mellersh,C.S.,Bannasch,D.L.: :
DNA Sequence Variants in the Five Prime Untranslated Region of the Cyclooxygenase-2 Gene Are Commonly Found in Healthy Dogs and Gray Wolves. PLoS One 10:e0133127, 2015. Pubmed reference: 26244515 . DOI: 10.1371/journal.pone.0133127 . |
2014 |
Whiteley,M.H.: :
Allelic variation in the canine Cox-2 promoter causes hypermethylation of the canine Cox-2 promoter in clinical cases of renal dysplasia. Clin Epigenetics 6:7, 2014. Pubmed reference: 24708682 . DOI: 10.1186/1868-7083-6-7 . |
2012 |
PLOSONEEditors: :
Expression of concern: Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs. PLoS One 7:e49703, 2012. Pubmed reference: 23145184 . DOI: 10.1371/journal.pone.0049703 . |
2011 |
Whiteley,MH.,Bell,JS.,Rothman,DA.: :
Novel allelic variants in the canine cyclooxgenase-2 (Cox-2) promoter are associated with renal dysplasia in dogs. PLoS One 6:e16684, 2011. Pubmed reference: 21346820 . DOI: 10.1371/journal.pone.0016684 . |
2010 |
Bruder,MC.,Shoieb,AM.,Shirai,N.,Boucher,GG.,Brodie,TA.: :
Renal dysplasia in Beagle dogs: four cases. Toxicol Pathol 38:1051-7, 2010. Pubmed reference: 20884818 . DOI: 10.1177/0192623310382558 . |
2010 |
Seiler,GS.,Rhodes,J.,Cianciolo,R.,Casal,ML.: :
Ultrasonographic findings in Cairn Terriers with preclinical renal dysplasia. Vet Radiol Ultrasound 51:453-7, 2010. Pubmed reference: 20806879 . |
2003 |
Bovee,K.C.: :
Renal dysplasia in Shih Tzu dogs. Proceedings of the 28th Congress of the World Small Animal Veterinary Association :http://www.vin.com/proceedings/Proceedings.plx?CID=WSAVA2003&PID=6602&O=Generic, 2003. |
2001 |
Ohara,K.,Kobayashi,Y.,Tsuchiya,N.,Furuoka,H.,Matsui,T.: :
Renal dysplasia in a Shih Tzu dog in Japan. J Vet Med Sci 63:1127-30, 2001. Pubmed reference: 11714030 . |
2000 |
Hoppe,A.,Karlstam,E.: :
Renal dysplasia in boxers and Finnish harriers Journal of Small Animal Practice 41:422-426, 2000. Pubmed reference: 11023130 . |
1999 |
Olenick,C.L.: :
Congenital renal dysplasia and psychogenic polydipsia in a Bernese mountain dog Canadian Veterinary Journal - Revue Veterinaire Canadienne 40:425-426, 1999. |
1998 |
Schulze,C.,Meyer,H.P.,Blok,A.L.,Schipper,K.,van,den,Ingh,T.S.G.A.M.: :
Renal dysplasia in three young adult Dutch kooiker dogs Veterinary Quarterly 20:146-148, 1998. Pubmed reference: 9810631 . |
1997 |
Felkai,C.,Voros,K.,Vrabely,T.,Vetesi,F.,Karsai,F.,Papp,L.: :
Ultrasonographic findings of renal dysplasia in Cocker Spaniels - eight cases Acta Veterinaria Hungarica 45:397-408, 1997. Pubmed reference: 9557317 . |
1997 |
Gross,T.L.: :
Calcinosis circumscripta and renal dysplasia in a dog Veterinary Dermatology 8:27-31, 1997. |
1997 |
Miyamoto,T.,Wakizaka,S.,Matsuyama,S.,Baba,E.,Ohashi,F.,Kuwamura,M.,Yamate,J.,Kotani,T.: :
A control of a Golden Retriever with renal dysplasia Journal of Veterinary Medical Science 59:939-942, 1997. Pubmed reference: 9362046 . |
1996 |
Lobetti,R.G.,Pearson,J.,Jimenez,M.: :
Renal dysplasia in a Rhodesian Ridgeback dog Journal of Small Animal Practice 37:552-555, 1996. Pubmed reference: 8934429 . |
1995 |
Kerlin,R.L.,Vanwinkle,T.J.: :
Renal dysplasia in Golden Retrievers Veterinary Pathology 32:327-329, 1995. Pubmed reference: 7604504 . |
1989 |
Murphy,M.G.: :
Renal Dysplasia in a Cavalier King Charles Spaniel Irish Veterinary Journal 42:96-97, 1989. |