The detail information of Melanoma
Basic Information

Disease Description: A rare cancer developing from the type of skin cell which produces pigment (melanin).

Inherit Mode: -

Disease Symptom: Benign Melanomas: Benign cutaneous melanomas of dogs are usually seen as round, firm, raised, darkly pigmented masses from one-quarter to 2 inches in diameter. They occur most often on the head, digits or back. Malignant Melanomas: Lymph node swelling or enlargement may be a clinical sign of malignant spread of a melanoma. An abnormally concentrated amount of melanin (pigment) is often another hallmark of melanomas. However, some melanomas do not display the characteristic darkly pigmented color of most melanomas.

Disease Cause: -

Disease Diagnose: A definitive diagnosis is made via microscopic analysis (histopathology evaluation by a Specialist in Veterinary Pathology) of a small section of the growth. Also called a tumor biopsy, the examining pathologist usually will grade the specimen according to how actively the cells are replicating. This gives an approximation of how likely the growth is to invade and spread. If an entire growth is removed, the pathologist can report on the tissue's grade as well as any evidence that parts of the tumor may not have been thoroughly excised by the surgeon.

Treat Method: Treatment of melanomas is best provided by surgical excision of the tumor and nearby surrounding tissue. Localized tumors may be completely removed and the patient cured. However, if a malignant melanoma has had the opportunity to spread to distant areas of the body, the prognosis for the dog is not favorable. Chemotherapy has been performed with marginal success, though complete remissions of metastatic melanoma cases are rare. Fortunately most cutaneous (skin) melanomas are benign; nevertheless, individual growths should be evaluated carefully as any given melanoma may become malignant.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Melanoma, congenital - - - -
Melanoma, malignant - - - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB78 Cocker Spaniel Happy, smart, gentle 36.8-39.4 cm (male), 34.3-36.8 cm (female) 11.3-13.6 kg (male), 9.1-11.3 kg (female)
CB98 English Toy Spaniel Affectionate, Alert, Merry 22.9-25.4 cm 3.6-6.4 kg England
CB112 German Spitz Devoted, Lively, Attentive 12-15 inches 24-26 pounds Germany
CB142 Irish Blue Terrier Smart and alert; people oriented, with a dash of Irish humor in his heart 45.7-49.5 cm (male), 44.5-48.3 cm (female) 15-18.1 kg (male), females weigh slightly less than males Ireland
CB148 Lagotto Romagnolo(Romagna Water Dog) Easygoing, affectionate, and eager to please 43.2-48.3 cm (male), 40.6-45.7 cm (female) 12.9-15.9 kg (male), 10.9-14.1 kg (female) Italy
CB215 Sealyham Terrier Alert and outgoing; stubbornness is tempered by a sly sense of humor 26.7 cm 10.4-10.9 kg (male), slightly less (females) United Kingdom (Wales)
References
2021 Tani,H.,Miyamoto,R.,Noguchi,S.,Kurita,S.,Nagashima,T.,Michishita,M.,Yayoshi,N.,Tamura,K.,Bonkobara,M.: :
A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis. BMC Vet Res 17:147, 2021.
Pubmed reference: 33827546 . DOI: 10.1186/s12917-021-02864-3 .
2018 Jama,N.,Farquhar,N.,Butt,Z.,Coupland,S.E.,Sacco,J.J.,Scase,T.,Fielding,A.B.,Coulson,J.M.,Kalirai,H.,Killick,D.R.: :
Altered Nuclear Expression of the Deubiquitylase BAP1 Cannot be Used as a Prognostic Marker for Canine Melanoma. J Comp Pathol 162:50-58, 2018.
Pubmed reference: 30060843 . DOI: 10.1016/j.jcpa.2018.06.007 .
2017 Meyrer,B.,Bianchi,S.P.,Pavarini,S.P.,Gerardi,D.G.: :
Congenital cutaneous melanoma in a dog. Vet Dermatol 28:228-e56, 2017.
Pubmed reference: 27813258 . DOI: 10.1111/vde.12391 .
2016 Gramer,I.,Kessler,M.,Geyer,J.: :
Detection of novel polymorphisms in the ckit gene of canine patients with lymphoma, melanoma, haemangiosarcoma, and osteosarcoma. Vet Res Commun 40:89-95, 2016.
Pubmed reference: 26971271 . DOI: 10.1007/s11259-016-9653-x .
2013 Chu,P.Y.,Pan,S.L.,Liu,C.H.,Lee,J.,Yeh,L.S.,Liao,A.T.: :
KIT gene exon 11 mutations in canine malignant melanoma. Vet J 196:226-30, 2013.
Pubmed reference: 23069279 . DOI: 10.1016/j.tvjl.2012.09.005 .
2013 Dobson,J.M.: :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013.
Pubmed reference: 23738139 . DOI: 10.1155/2013/941275 .
2011 Murakami,A.,Mori,T.,Sakai,H.,Murakami,M.,Yanai,T.,Hoshino,Y.,Maruo,K.: :
Analysis of KIT expression and KIT exon 11 mutations in canine oral malignant melanomas. Vet Comp Oncol 9:219-24, 2011.
Pubmed reference: 21848624 . DOI: 10.1111/j.1476-5829.2010.00253.x .
2009 London,C.A.,Malpas,P.B.,Wood-Follis,S.L.,Boucher,J.F.,Rusk,A.W.,Rosenberg,M.P.,Henry,C.J.,Mitchener,K.L.,Klein,M.K.,Hintermeister,J.G.,Bergman,P.J.,Couto,G.C.,Mauldin,G.N.,Michels,G.M.: :
Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision. Clin Cancer Res 15:3856-65, 2009.
Pubmed reference: 19470739 . DOI: 10.1158/1078-0432.CCR-08-1860 .
2003 Sulaimon,S.S.,Kitchell,B.E.: :
The basic biology of malignant melanoma: molecular mechanisms of disease progression and comparative aspects. J Vet Intern Med 17:760-72, 2003.
Pubmed reference: 14658711 .
1992 Mayr,B.,Eschborn,U.,Schleger,W.,Loupal,G.,Burtscher,H.: :
Cytogenetic studies in a canine malignant melanoma. J Comp Pathol 106:319-22, 1992.
Pubmed reference: 1602064 .