Disease Detail Information

The detail information of Factor VII deficiency

Basic Information

Disease Description: A mild bleeding disease primarily of beagle dogs.

Inherit Mode: -

Disease Symptom: -

Disease Cause: Canine coagulation factor VII deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated.

Disease Diagnose: A canine specific factor VII ELISA is available to diagnose this condition.Routine coagulation screening tests can also be employed and unlike factor VIII or factor X deficiency, partial thromboplastin time in factor VII deficient dogs is usually normal.Treatment usually involves use of frozen fresh plasma or recombinant factor VII[8] is available in life-threatening situations.Use of recombinant factor VII offers only a temporary solution because the half-life of FVII protein is only 3 - 4 hours and, in canines, treatment with human proteins raises concern about antibody responses to those proteins, thus potentially limiting further therapy.Gene therapy has shown promise recently, but has been complicated by the canine immune response to adeno-associated viral gene transfer vector capsid proteins used in canine patients

Treat Method: -

Breeder Advice: -

Disease Description Source: Link

Associated Diseases

Disease Name	Other Name	Mode of inheritance	Link ID	Possible OMIM ID	Gene
Factor VII deficiency	-	Autosomal Recessive			F7
	CIDD	-	-

Associated Breeds

iDog Breed Number	Breed Name	Personality	Height	Weight	Breed Source
CB5	Alaskan Malamute	Affectionate, loyal, playful but dignified	63.5 cm (male), 58.4 cm (female)	38.6 kg (male), 34 kg (female)	United States
CB23	Bavarian Mountain Scent Hound	Loyal, Versatile, Reserved with Strangers	17-20.5 inches	37-66 pound
CB25	Bearded Collie	Bouncy, charismatic, friendly; smart, but also stubborn and independent	53.3-55.9 cm (male), 50.8-53.3 cm (female)	20.4-24.9 kg	United Kingdom (Scotland)

References

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