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Simian virus 41 - SV41

Virus Host Enzyme Edited Genes Phenotype Disease Details
Simian virus 41 Human; Monkey NA phosphoprotein gene Produce new protein Paramyxoviruses
  • Edited Gene Alias: P gene
  • Editing Site: NA
  • Editing Type: G insertion
  • Amino Acid Change: NA
  • Editing Level: Present
  • Molecular Consequence: NA
  • Correlation: NA
  • Description: The researchers have demonstrated that RNA-editing events occur in SV41 P gene transcripts and that the ratio of edited mRNAs to faithfully copied mRNA (P-mRNA:V-mRNA) is about 1:5 at either 24 or 40 h post-infection. The mRNA with two G insertions was capable of encoding a P protein of 395 amino acids with a predicted M(r) of 41,992. A kinetic study of P and V proteins by Western blot analysis showed that in virus-infected cells the amounts of both proteins were almost equal although the V-mRNA was considerably more abundant than the P-mRNA. Alignment of the SV41 P and V proteins with those of nine other paramyxoviruses demonstrated that irregular gaps were present around the RNA-editing sites.
  • PMID: 8492098