Gene symbol | PODXL |
---|---|
Aliases | - |
Protein Name | Podocalyxin |
Function | Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to Increased activities of the MAPK and PI3K pathways in cancer cells. |
Species | Human |
Editing Sites | 1 |
Disease | Gastric Cancer; |
Description | RNA misediting is closely associated with GC pathogenesis, the ADAR2-regulated recoding PODXL gene at codon 241 (His to Arg) confers a loss-of-function phenotype that neutralizes the tumorigenic ability of the unedited PODXL. |
RADR | RADAR |
REDIportal | REDI portal |
External links | O00592(Uniport); NM_001018111 (NM id); 5420 (NCBI gene id); GeneCard; GTEx |
Sequence |
Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 241 | 1091 | CAG->CGG | H->R | Nonsynonymous substitution | Absence | Gastric | RNA editing confers a loss-of-function phenotype that neutralizes the tumorigenic ability of the unedited PODXL. | Reduce tumorigenic ability |