EDK
Editome Disease Knowledgebase
IGFBP7
| Gene symbol | IGFBP7 |
|---|---|
| Aliases | - |
| Protein Name | Insulin-like growth factor-binding protein 7 |
| Function | The major function of the protein is the regulation of the availability of insulin-like growth factors (IGFs) in tissue as well as in modulating IGF binding to its receptors. Insulin-like growth factor-binding protein-7 (IGFBP7) was suggested to function as a tumor suppressor gene in several cancers, and to play a role in the proliferation of keratinocytes. RNA-editing will change the protease recognition site of matriptase to stabilize the IGFBP7 protein. |
| Species | Human |
| Editing Sites | 3 |
| Disease | Esophageal Squamous Cell Carcinoma; Squamous Cell Carcinoma; Basal Cell Carcinoma; |
| Description | RNA editing in IGFBP7 promotes cell apoptosis in the tumor, but the inadequate A-to-I editing of IGFBP7 may be used by tumor cells to escape the cellular control of proliferation. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | Q16270(Uniport); NM_001553 (NM id); 3490 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Interaction | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 95 | 318 | AAG->AGG | K->R | Nonsynonymous substitution | Increased | Esophageal | Change the protease recognition site of matriptase to stabilize the IGFBP7 protein | The hyperediting patterns of FLNB might play a role in ESCC progression. | Promote tumor cell apoptosis | ||
|
A-to-I | CDS | 78 | 266 | AGG->GGG | R->G | Nonsynonymous substitution | Decreased | Epidermis | NA | Inadequate A-to-I editing of IGFBP7 may be used by tumor cells to escape cellular control of proliferation. | Promote tumor cell proliferation | ||
|
A-to-I | CDS | 95 | 318 | AAG->AGG | K->R | Nonsynonymous substitution | Decreased | Epidermis | NA | Inadequate A-to-I editing of IGFBP7 may be used by tumor cells to escape cellular control of proliferation. | Promote tumor cell proliferation | ||
|
NA | CDS | NA | NA | NA | NA | Nonsynonymous substitution | Decrease | Psoriatic lesions; Uninvolved skin; Healthy control skin samples | NA | NA | Exacerbation the psoriasis |