EDK
Editome Disease Knowledgebase
COPA
| Gene symbol | COPA |
|---|---|
| Aliases | - |
| Protein Name | Coatomer subunit alpha |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The hyper-editing of COPA are closely associated with Hepatocellular Carcinoma pathogenesis. |
| Species | Human |
| Editing Sites | 1 |
| Disease | Hepatocellular Carcinoma; Esophageal Squamous Cell Carcinoma; |
| Description | The hyper-editing of COPA are closely associated with hepatocellular carcinoma pathogenesis. And in the hepatocellular carcinoma samples, COPA editing level is significantly lower than normal samples. The previous study has identified two RNA-editing sites at codon 164 (Ile-Val) of the COPA gene. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | P53621(Uniport); NM_001098398 (NM id); 1314 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 164 | 884 | AUU->GUU | I->V | Nonsynonymous substitution | Decreased | Liver | The hyperediting of COPA are closely associated with HCC pathogenesis. | Affect tumor pathogenesis | ||
|
NA | CDS | NA | NA | NA | NA | Nonsynonymous substitution | Decrease | Psoriatic lesions; Uninvolved skin; Healthy control skin samples | NA | Exacerbation the psoriasis |