EDK
Editome Disease Knowledgebase
CDK13
| Gene symbol | CDK13 |
|---|---|
| Aliases | - |
| Protein Name | Cyclin-dependent kinase 13 |
| Function | The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described. |
| Species | Human |
| Editing Sites | 2 |
| Disease | Hepatocellular Carcinoma; |
| Description | The K96R editing site of CDK13 and Q103R, which were specifically modified by ADAR1，were more abundant in HCC tumor tissues and closely associated with poor prognosis of HCC patients. |
| RADR | RADAR |
| REDIportal | REDI portal |
| External links | Q14004(Uniport); NM_003718 (NM id); 2316 (NCBI gene id); GeneCard; GTEx |
| Sequence |
Editing sites
| Enzyme | Editing type | Region | AA Seq Position | NT Seq Position | Codon Change | Amino Acid Change | Molecular Consequence | Editing Level | Tissue | Editing Effect | Phenotype | Disease name | PMID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A-to-I | CDS | 96 | 569 | AAG->AGG | K->R | Nonsynonymous substitution | Increased | Liver | NA | Affect HCC tumor tissues and associated with poor prognosis | ||
|
A-to-I | CDS | 103 | 590 | CAG->CGG | Q->R | Nonsynonymous substitution | Increased | Liver | NA | Affect HCC tumor tissues and associated with poor prognosis |