EDK
Editome Disease Knowledgebase
Glioblastoma
| Disease name | Glioblastoma |
|---|---|
| Classfication | Cancer |
| Related Enzyme(s) | |
| EFO | EFO:0000519 |
| DOID | 3068 |
| OMIM | |
| NCI | |
| Definition | An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has material basis in abnormally proliferating cells derives from multiple cell types including astrocytes and oligondroctyes. |
| Gene symbol | Species | Enzyme | Editing site(s) | Editing Type | PMID | RADAR | REDIportal | Description |
|---|---|---|---|---|---|---|---|---|
| CDC14B | Human | ADAR2 | 13 | A-to-I | CDC14B editing and expression are progressively impaired in astrocytomas from grade I to IV, being very low in GBMs. | |||
| COG3 | Human | ADAR2 | 1 | NA | Over-editing (>40%) at the COG3 I/V site plays a critical pro-tumoral role in GBM and correlates with a worse prognosis in GBM patients. |
| Gene symbol | Disease | Enzyme | Editing Sites | Editing Type | miRBase | PMID | Description |
|---|---|---|---|---|---|---|---|
| hsa-miR-589-3p | ADAR2 | 3 | A-to-I | MIMAT0003256 | miR-589-3p is a unique miRNA almost fully edited (100%) in normal brain and with a consistent editing decrease in glioblastoma. The edited version of miR-589-3p inhibits glioblastoma cell proliferation, migration and invasion, while the unedited version boosts cell proliferation and motility/invasion. | ||
| hsa-miR-221 | ADAR2 | 2 | A-to-I | MI0000298 | ADAR2 edits miR-221 precursors and decreases the expression of the corresponding mature onco-miRNAs in vivo and in vitro, with important effects on cell proliferation and migration. | ||
| hsa-miR-222 | ADAR2 | 2 | A-to-I | MI0000299 | ADAR2 edits miR-222 precursors and decreases the expression of the corresponding mature onco-miRNAs in vivo and in vitro, with important effects on cell proliferation and migration. |