National Genomics Data Center

BIG Search

BIG Search is a scalable text search engine built based on ElasticSearch (a highly scalable open-source full-text search and analytics engine based on Apache Lucene). It features cross-domain search and facilitates users to gain access to a wide range of biomedical data, not only from NGDC databases but also partner databases throughout the world.

e.g., PRJCA000126;SAMC000385;tp53;EGFR; human; KaKs_Calculator

Total 3 record(s) from BioProject

BioProject: Study on plasma ctDNA dynamic gene changes in patients with EGFR-mutation in non-small cell lung cancer

  • Accession: PRJCA004723
  • Title: Study on plasma ctDNA dynamic gene changes in patients with EGFR-mutation in non-small cell lung cancer
  • Description: Dynamic cfDNA Analysis by NGS in EGFR-T790M positive advanced NSCLC patients failed to the first-generation EGFR-TKIs
  • BasicInfo : PRJCA004723; Raw sequence reads Genome sequencing ; Medical

BioProject: Heterogeneity of progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex

  • Accession: PRJCA003555
  • Title: Heterogeneity of progenitor cells during the neurogenesis-to-gliogenesis switch in the developing human cerebral cortex
  • Description: In this study, by sorting EGFR+ cells that were sampled from the human cerebral cortex between gestational week (GW) 21 and GW 26, we characterized the molecular features of various progenitor cells through single-cell RNA sequencing.
  • BasicInfo : PRJCA003555; Transcriptome or Gene expression; Medical

BioProject: Characteristics of pan-cancer patients with ultrahigh tumor mutation burden

  • Accession: PRJCA004800
  • Title: Characteristics of pan-cancer patients with ultrahigh tumor mutation burden
  • Description: Tumor mutation burden has been proven to be a good predictor for the efficacy of immunotherapy, especially in patients with hypermutation. However, most research focused on the analysis of hypermutation in individual tumors, and there is a lack of integrated research on the hypermutation across different cancers. This study aimed to characterize hypermutated patients to distinguish between these patients and nonhypermutated patients. Among the 5,980 tumor samples, 1,164 were selected as samples with hypermutation. Compared with the nonhypermutated group, a significant increase in the mutation rates of DNA mismatch repair genes and polymerase genes was detected in the hypermutated group, and there was an overlap between high TMB and high microsatellite instability or high PD-L1. In addition, we found that EGFR, KRAS and PIK3CA had a high frequency of both single nucleotide variation and copy number variation mutations. These identified mutant genes were enriched in the oncogenic signaling pathway and the DNA damage repair pathway. At the same time, the somatic cell characteristics and distribution of the two groups were significantly different.
  • BasicInfo : PRJCA004800; Targeted Locus (Loci); Medical