Another Name: Uveodermatological syndrome

Abbreviated Name: VKH

Disease Description: An autoimmune disease common in Akitas and the "sled" dog breeds where the eyes, blood and other tissues are progressively destroyed leading to blindness and death.

Inherit Mode: -

Disease Symptom: Symptoms may include: Inflammation of the eyes; Bloodshot eyes; Excessive tearing; Squinting; Sensitivity to light; Whitening of the coat, skin, nose, lips, nails, footpads and scrotum ;A black dog slowly turns solid white.

Disease Cause: 1.Vogt- Koyanagi-Harada Syndrome in dogs is believed to be an auto-immune disease; this means that the body’s immune system attacks its own cells .2.Genetic - inherited. 3.Some researchers believe that the disease is triggered by a viral infection

Disease Diagnose: In addition to a physical exam where the veterinarian may check your dog’s temperature, pulse and blood pressure, he will perform an ocular exam, which may include a pupillary light reflex test. Further investigation may include a Schirmer tear test, measurement of the intraocular pressure, and a checking of the interior of the eye. The doctor will also recommend taking a complete blood count and a serum chemistry panel. If the veterinarian suspects Vogt-Koyanagi-Harada syndrome he may also want to take a skin biopsy test.

Treat Method: Once VKH is diagnosed, the veterinarian will want to start your dog on immunosuppression therapy which may include systemic and topical anti-inflammatory medications. The dosage of the medications will vary with each canine depending on the severity of the symptoms. Most veterinarians will start the patient on higher doses of medications and then taper off once the disease is in remission. Your dog might be prescribed prednisone and then azathioprine (once in remission). Immunosuppression drugs may have side effects such as increased thirst, hunger, susceptibility to bacterial infections, loss of energy, vomiting and panting. Steroid eye drops or injections of steroids may be administered into the patient’s conjunctival membrane.

Breeder Advice: Although there is no known cure for Vogt-Koyanagi-Harada syndrome in dogs, the disease can be kept under control with long-term immunosuppressive medication. It is important to follow the veterinarian’s treatment plan. The patient must have regular follow-up visits to monitor his progress and to evaluate if there are any side effects to the medications. Regular ocular exams and tests must be performed to help assess any further damage to your dog’s eyes. Dogs that have partial eyesight loss or blindness can still live full and happy lives with your patience and assistance.

Disease Description Source: Link