Disease Description: A condition where the tubules of the kidneys (the filtering structures) do not function properly (See #124b.) In basenjis, glycosuria develops and is called Fanconi syndrome.

Inherit Mode: -

Disease Symptom: -

Disease Cause: -

Disease Diagnose: Type I renal tubular acidosis has been associated with demineralization of the skeleton (due to buffering of excess hydrogen ions) and nephrolithiasis (due to hypercalciuria from bone resorption) in dogs. Diagnosis is based on the presence of hyperchloremic metabolic acidosis with a urinary pH that is inappropriately high for the degree of systemic acidosis in the absence of bacterial urease modification of urine. Failure to produce acid urine in the face of metabolic acidosis or after oral ammonium chloride loading is diagnostic; however, this challenge test is contraindicated in animals that are already severely acidotic. Type II renal tubular acidosis is diagnosed by demonstrating increased urinary fractional excretion of bicarbonate when plasma bicarbonate levels are normal or decreased; this test is not practicable in the clinical setting and diagnosis is presumptively based on history, signalment, and clinical pathology findings.

Treat Method: Therapy consists of oral administration of an alkalinizing agent sufficient to maintain normal blood pH (1 mEq bicarbonate equivalent/kg/day for Type I and 1–6 mEq bicarbonate equivalent/kg/day for Type II, PO).

Breeder Advice: Therapy is more problematic in dogs with Type II renal tubular acidosis, because supplemental bicarbonate is readily lost in the urine.

Disease Description Source: Link