The detail information of Mastocytoma
Basic Information

Disease Description: A rare cancer developing from a type of tissue cell known as a mast cell.

Inherit Mode: -

Disease Symptom: The mastocytoma is sometimes called as "the great deceiver" as it can show up with a wide range of appearances and clinical signs. The skin growths of mast cell tumors can be single or multiple, small and pale, or large, red and inflamed. They can be superficial or deeper in the dermis. The size of the growth may change. Those changes are the result of histamine release by the cancer. Touching or rubbing the growth may cause it to grow and become red and inflamed. Rarely, dogs will show signs of stomach upset and gastric ulcers such as vomiting and black stool. Interference with blood clotting and kidney inflammation are also seen.

Disease Cause: -

Disease Diagnose: -

Treat Method: Treatment of mast cell tumors employs a wide variety of techniques because of the stubborn nature of this type of tumors. Surgical removal of the affected and surrounding areas of the skin is usually the first step taken. Following surgical recovery, extensive radiation therapy and chemotherapy may be employed to help reduce the chances of recurrence and metastatic growth. Cryotherapy is also used in those instances in which surgical removal of the tumor is incomplete or impossible.

Breeder Advice: -

Disease Description Source: Link

Associated Diseases
Disease Name Other Name Mode of inheritance Link ID Possible OMIM ID Gene
Mast cell tumour - Multifactorial - -
Associated Breeds
iDog Breed Number Breed Name Personality Height Weight Breed Source
CB45 Borzoi(Russian wolfhound) Loyal, affectionate, regally dignified; a charming but independent-minded canine nobleman 71.1 cm & up (male), 66 cm & up (female) 34-47.6 kg (male), 27.2-38.6 kg (female) Russia
CB47 Bouvier des Flandres(Flanders Cattle Dog) Strong-willed, even-tempered, courageous; affectionate with family, intimidating to intruders 62.2-69.9 cm (male), 59.7-67.3 cm (female) 31.8-49.9 kg Belgium
CB49 Boykin Spaniel Friendly, eager, trainable, lovable 39.4-45.7 cm (male), 35.6-41.9 cm (female) 13.6-18.1 kg (male), 11.3-15.9 kg (female) United States
CB58 English Bulldog Calm, courageous, and friendly; dignified but amusing. 35.6-38.1 cm 22.7 kg (male), 18.1 kg (female) United Kingdom (England)
CB197 Hungarian Puli Loyal, smart, home-loving; strong-willed but trainable 43.2 cm (male), 40.6 cm (female) 11.3-15.9 kg Hungary
CB253 Welsh Springer Spaniel Happy, upbeat, family oriented; reserved but not shy with strangers 45.7-48.3 cm (male), 43.2-45.7 cm (female) 18.1-24.9 kg (male), 15.9-22.7 kg (female) United Kingdom (Wales)
References
2019 Biasoli,D.,Compston-Garnett,L.,Ricketts,S.L.,Birand,Z.,Courtay-Cahen,C.,Fineberg,E.,Arendt,M.,Boerkamp,K.,Melin,M.,Koltookian,M.,Murphy,S.,Rutteman,G.,Lindblad-Toh,K.,Starkey,M.: :
A synonymous germline variant in a gene encoding a cell adhesion molecule is associated with cutaneous mast cell tumour development in Labrador and Golden Retrievers. PLoS Genet 15:e1007967, 2019.
Pubmed reference: 30901340 . DOI: 10.1371/journal.pgen.1007967 .
2019 Vozdova,M.,Kubickova,S.,Fictum,P.,Fröhlich,J.,Jelinek,F.,Rubes,J.: :
Prevalence and prognostic value of c-kit and TP53 mutations in canine mast cell tumours. Vet J 247:71-74, 2019.
Pubmed reference: 30971355 . DOI: 10.1016/j.tvjl.2019.03.005 .
2015 Arendt,M.L.,Melin,M.,Tonomura,N.,Koltookian,M.,Courtay-Cahen,C.,Flindall,N.,Bass,J.,Boerkamp,K.,Megquir,K.,Youell,L.,Murphy,S.,McCarthy,C.,London,C.,Rutteman,G.R.,Starkey,M.,Lindblad-Toh,K.: :
Genome-Wide Association Study of Golden Retrievers Identifies Germ-Line Risk Factors Predisposing to Mast Cell Tumours. PLoS Genet 11:e1005647, 2015.
Pubmed reference: 26588071 . DOI: 10.1371/journal.pgen.1005647 .
2013 Bellumori,T.P.,Famula,T.R.,Bannasch,D.L.,Belanger,J.M.,Oberbauer,A.M.: :
Prevalence of inherited disorders among mixed-breed and purebred dogs: 27,254 cases (1995-2010). J Am Vet Med Assoc 242:1549-55, 2013.
Pubmed reference: 23683021 . DOI: 10.2460/javma.242.11.1549 .
2013 Dobson,J.M.: :
Breed-predispositions to cancer in pedigree dogs. ISRN Vet Sci 2013:941275, 2013.
Pubmed reference: 23738139 . DOI: 10.1155/2013/941275 .
2013 Warland,J.,Dobson,J.: :
Breed predispositions in canine mast cell tumour: A single centre experience in the United Kingdom. Vet J :, 2013.
Pubmed reference: 23583004 . DOI: 10.1016/j.tvjl.2013.02.017 .