DAC NO.: HDAC000146
DAC name: Stem Cell Therapy Committee
Contact person: Xue Zhigang
URL: https://med.tongji.edu.cn/info/1406/4503.htm
Description: Although many efforts were spent to treat Corona Virus Disease 2019 (COVID-19), the pathogenesis and effective treatments were still absent. We performed human umbilical cord mesenchymal stem cells (hUC-MSCs) treatment for mild/moderate COVID-19 cases. Gene expression profile were detected using single-cell RNA and V(D)J sequencing. We found the functional improvement of effector memory CD4+ T cells, promotion of the anti-infective activities in effector CD8+ T cells, NK cells and plasma cells in convalescent patients after MSCs treatments. We further identified 6 high frequency T cell clonotypes. Notably, we found the global downregulation of AP-1 subunits and dysfunction of ribosomal subunits, which may affect inflammatory response and virus replication. Our results demonstrated the effects of MSCs treatments for mild/ moderate COVID-19 at single-cell resolution.
