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HRA005166
   HRA005166.xlsx
Title:
DNA methylation profiling to determine the primary sites of metastatic cancers using formalin-fixed paraffin-embedded tissues
Release date:
2023-08-17
Description:
Identifying the primary site of metastatic cancer is critical to guiding the subsequent treatment. Approximately 3-9% of metastatic patients are diagnosed with cancer of unknown primary sites (CUP) even after a comprehensive diagnostic workup. However, a widely accepted molecular test is still not available. Here, we report a new method that applies formalin-fixed, paraffin-embedded tissues to construct reduced representation bisulfite sequencing libraries (FFPE-RRBS). We then generate and systematically evaluate 28 molecular classifiers, built on four DNA methylation scoring methods and seven machine learning approaches, using the RRBS library dataset of 498 fresh-frozen tumor tissues from primary cancer patients.
Data Accessibility:   
Controlled access Request Data
BioProject:
PRJCA018404
Study type:
Disease Study
Disease name:
Cancer
Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.


DAC NO.:
HDAC002855
DAC name:
BELIVE
Contact person:
Gu Hongcang
Email:
gu_hongcang@cmpt.ac.cn
Description:
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Individuals & samples
Files
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Submitter:   Shi Jiantao / jtshi@sibcb.ac.cn
Organization:   Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences
Submission date:   2023-07-16
Requests:   -