Excessive serine impairs thrombopoiesis through inhibition of SVIL in Multiple Myeloma
Release date:
2023-01-27
Description:
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM. In addition, we identify serine, which is released from MM cells into the bone marrow microenvironment, as a key metabolic factor that suppresses megakaryopoiesis and thrombopoiesis. We exploring the key genes that regulated by serine through ATAC-seq, and provide potential therapeutic strategies for treating MM patients by targeting thrombocytopenia.
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HRA003852.xlsx