Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma
Release date:
2023-01-27
Description:
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM. In addition, we identify serine serves as a key metabolic factor that suppresses megakaryopoiesis and thrombopoiesis. We exploring the key genes that regulated by serine through RNA-seq, and provide potential therapeutic strategies for treating MM patients by targeting thrombocytopenia.
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HRA003851.xlsx