Tibetans are genetically adapted to high altitude environments.we present whole genome sequencing data of 1001, covering the major populated areas of the Qinghai-Tibetan Plateau in China. We identified 35 million variants and utilizing the large-scale WGS data, we constructed a comprehensive map of allele frequency and linkage disequilibrium, and provided a population-specific genome reference panel (referred as 1KTGP). Moreover, with the use of a combined approach, we relocated the signatures of Darwinian positive selection in the Tibetan genome.Overall, the large-scale Tibetan WGS data and the identified adaptive variants/genes can serve as a valuable resource for future genetic and medical studies of high altitude populations.
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[path/to/ascp]: Microsoft Windows: C:\Program Files\Aspera\Aspera Connect\bin\ascp.exe or
c:\users\[username]\AppData\Local\Programs\Aspera\Aspera Connect\bin\ascp.exe
Mac OS X: /Applications/Aspera/Connect.app/Contents/Resources/ascp (for admin's installation) or
/Users/[username]/Applications/Aspera/Connect.app/Contents/Resources/ascp (for non-admin's installation)
Linux: /opt/aspera/bin/ascp or
/home/[username]/aspera/connect/bin/ascp
[path/to/key/file] must be an absolute path, e.g.: /home/keys/aspera.openssh
[path/to/folder/containing/files] needs to specify the local folder that contains all the files to upload.