Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19
Release date:
2021-01-23
Description:
Here, we profiled the single-cell transcriptomes of 96,313 peripheral blood mononuclear cells (PBMCs) derived from 12 COVID-19 patients (including four moderate, four severe and four critical cases) and 3 healthy donors. Our work uncovers the cellular and molecular players underlying the disordered and heterogeneous immune responses associated with COVID-19 severity, which could provide valuable insights for the treatment of critical COVID-19 patients.
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