The Mutational landscape of Immunoglobulin D myeloma impacts patient outcomes
Release date:
2020-12-31
Description:
IgD multiple myeloma (MM) is a rare plasma cell dyscrasias with extremely poor prognosis and remains a lethal malignancy; whether there is an IgD isotype-specific genomic signature and, if so, how it differs from non-IgD MM is uncertain. To discover genetic alterations that impact IgD MM patient outcomes, we performed a whole-exome sequencing analysis of 34 patients with IgD MM and 61 non-IgD MM controls, respectively. We observed the diversity of mutational patterns within the IgD MM subgroup. We revealed the specific genetic landscape of IgD MM, identified clinically actionable mutations that may be better stratify IgD patients, and offers insights into new avenues for therapeutic options.
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HRA000529.xlsx