Nuclear SIRT3 counteracts human stem cell senescence
Release date:
2020-12-15
Description:
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase involved in various physiological and pathological processes. However, the role of SIRT3 in regulating human stem cell senescence remains largely unknown. Our study reveals a novel role of nuclear SIRT3 in stabilizing heterochromatin and counteracting hMSC senescence, which may provide new clinical therapeutic targets to ameliorate aging-related diseases.
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Organization: Institute of Zoology, Chinese Academy of Sciences
Submission date: 2020-11-13
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