NGDC - GSA for Human

HRA000365

HRA000365.xlsx

Title:

Integrated transcriptomic and epigenomic analyses reveal chamber- and species-specific characteristics of human and mouse hearts

Release date:

2021-03-28

Description:

Multi-omics analysis of hearts provides new insights into cardiac physiology and pathology. The transcriptome and epigenome characteristics of the mammalian heart are insufficiently revealed. Here, we applied the nucleosome occupancy and methylome sequencing (NOMe-seq), which detected DNA methylation and chromatin accessibility simultaneously, as well as RNA-seq, for multi-omics analysis of four chambers of both human and mouse adult hearts, as well as human fetal hearts. We identified differentially expressed genes between the atrium and the ventricle of human and mouse adult hearts, revealing both species-conserved and specific genes, particularly a number of novel lncRNAs. Genes associated with cardiac diseases showed chamber-specific expression patterns. DNA methylation distinguished between the atrium and the ventricle in both adult and fetal hearts, and human fetal and adult hearts showed distinct chromatin accessibility profiling.

Data Accessibility:

Controlled access Request Data

BioProject:

PRJCA003611

Study type:

Tissue study

Data Access Committee

For each controlled access study, there is a corresponding Data Access Committee(DAC) to determine the access permissions. Access to actual data files is not managed by NGDC.

DAC NO.:

HDAC000073

DAC name:

BIOPIC_TangLab

Contact person:

Tang Fuchou

Email:

tangfuchou@pku.edu.cn

Description:

Laboratory of Stem Cells and Epigenetics

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